Gut microbiomes of Malawian twin pairs discordant for kwashiorkor.
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor.
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DOI：
10.1126/science.1229000
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发表时间：
2013-02-01
期刊：
影响因子：
--
通讯作者：
Gordon JI
中科院分区：
文献类型：
--
作者：
Smith MI;Yatsunenko T;Manary MJ;Trehan I;Mkakosya R;Cheng J;Kau AL;Rich SS;Concannon P;Mychaleckyj JC;Liu J;Houpt E;Li JV;Holmes E;Nicholson J;Knights D;Ursell LK;Knight R;Gordon JI
营养不良是严重急性营养不良的一种神秘形式，是营养摄入不足加上额外环境损害的结果。为了研究肠道微生物组的作用，我们研究了317对出生后3年的马拉维双胞胎。在此期间，一半的双胞胎保持营养良好，而43%的双胞胎表现出营养不良，7%的双胞胎表现出急性营养不良。在患有营养不良的双胞胎中，两个孩子都用花生为基础的即食治疗食品（RUTF）进行治疗。时间序列宏基因组研究显示，RUTF在kwashiorkor微生物组中产生了代谢功能的短暂成熟，当RUTF停止时，代谢功能会退化。先前从几个不一致的配对中冷冻的粪便群落被分别移植到非生物小鼠体内。马拉维饮食和kwashiorkor微生物组的组合在受体小鼠中产生了显著的体重减轻，同时伴随着氨基酸、碳水化合物和中间代谢的扰动，RUTF只能暂时改善这些代谢。这些发现暗示肠道微生物群是导致营养不良的一个因素。
Kwashiorkor, an enigmatic form of severe acute malnutrition, is the consequence of inadequate nutrient intake plus additional environmental insults. To investigate the role of the gut microbiome, we studied 317 Malawian twin pairs during the first 3 years of life. During this time, half of the twin pairs remained well-nourished, while 43% became discordant and 7% manifested concordance for acute malnutrition. Both children in twin pairs discordant for kwashiorkor were treated with a peanut-based, ready-to-use therapeutic food (RUTF). Time-series metagenomic studies revealed that RUTF produced a transient maturation of metabolic functions in kwashiorkor microbiomes that regressed when RUTF was stopped. Previously frozen fecal communities from several discordant pairs were each transplanted into gnotobiotic mice. The combination of Malawian diet and kwashiorkor microbiome produced marked weight loss in recipient mice, accompanied by perturbations in amino acid, carbohydrate and intermediary metabolism that were only transiently ameliorated with RUTF. These findings implicate the gut microbiome as a causal factor in kwashiorkor.
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影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
2.4
作者：
ITOH, T;FUJIMOTO, Y;SAITO, T
通讯作者：
SAITO, T
影响因子：
7.1
作者：
ARROYAVE, G;FUNES, CD;WILSON, D
通讯作者：
WILSON, D
DOI：
10.1073/pnas.0804812105
发表时间：
2008-10-28
影响因子：
11.1
作者：
Sokol, Harry;Pigneur, Benedicte;Langella, Philippe
通讯作者：
Langella, Philippe
影响因子：
7.1
作者：
ITTYERAH, TR;PEREIRA, SM;DUMM, ME
通讯作者：
DUMM, ME