Clinicopathological significance of loss of ARID1A immunoreactivity in ovarian clear cell carcinoma.
Clinicopathological significance of loss of ARID1A immunoreactivity in ovarian clear cell carcinoma.
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DOI：
10.3390/ijms11125120
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发表时间：
2010
影响因子：
5.6
通讯作者：
Shih IeM
中科院分区：
文献类型：
--
作者：
Maeda D;Mao TL;Fukayama M;Nakagawa S;Yano T;Taketani Y;Shih IeM
Recent genome-wide analysis has demonstrated that somatic mutations in ARID1A (BAF250) are the most common molecular genetic changes in ovarian clear cell carcinoma (OCCC). ARID1A mutations, which occur in approximately half of OCCC cases, lead to deletion of the encoded protein and inactivation of the putative tumor suppressor. In this study, we determined the significance of loss of ARID1A immunoreactivity with respect to several clinicopathological features in a total of 149 OCCCs. First, we demonstrated that ARID1A immunohistochemistry showed concordance with the mutational status in 91% of cases with 100% sensitivity and 66% specificity. Specifically, among 12 OCCC cases for which ARIDA mutational status was known, ARIDIA immunoreactivity was undetectable in all 9 cases harboring ARID1A mutations and was undetectable in one of 3 cases with wild-type ARID1A. With respect to the entire cohort, ARID1A immunoreactivity was undetectable in 88 (59%) of 149 OCCCs. There was no significant difference between ARID1A negative and positive cases in terms of histopathologic features, age, clinical stage, or overall survival. In conclusion, this study provides further evidence that mutations in ARID1A resulted in loss of ARID1A protein expression in OCCC, although no significant differences between ARID1A positive and negative cases were observed with respect to any clinicopathological features examined.
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DOI：
10.1016/j.bbrc.2009.05.115
发表时间：
2009-08-07
影响因子：
3.1
作者：
Van Rechem, Capucine;Boulay, Gaylor;Leprince, Dominique
通讯作者：
Leprince, Dominique
DOI：
10.1158/1078-0432.ccr-09-2105
发表时间：
2010-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kuo KT;Mao TL;Chen X;Feng Y;Nakayama K;Wang Y;Glas R;Ma MJ;Kurman RJ;Shih IeM;Wang TL
通讯作者：
Wang TL
DOI：
10.1056/nejmoa1008433
发表时间：
2010-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Wiegand KC;Shah SP;Al-Agha OM;Zhao Y;Tse K;Zeng T;Senz J;McConechy MK;Anglesio MS;Kalloger SE;Yang W;Heravi-Moussavi A;Giuliany R;Chow C;Fee J;Zayed A;Prentice L;Melnyk N;Turashvili G;Delaney AD;Madore J;Yip S;McPherson AW;Ha G;Bell L;Fereday S;Tam A;Galletta L;Tonin PN;Provencher D;Miller D;Jones SJ;Moore RA;Morin GB;Oloumi A;Boyd N;Aparicio SA;Shih IeM;Mes-Masson AM;Bowtell DD;Hirst M;Gilks B;Marra MA;Huntsman DG
通讯作者：
Huntsman DG
DOI：
10.1126/science.1196333
发表时间：
2010-10-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jones S;Wang TL;Shih IeM;Mao TL;Nakayama K;Roden R;Glas R;Slamon D;Diaz LA Jr;Vogelstein B;Kinzler KW;Velculescu VE;Papadopoulos N
通讯作者：
Papadopoulos N
影响因子：
64.8
作者：
通讯作者：
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