Chromatin remodelling during development.
Chromatin remodelling during development.
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染色质全基因组分析的新方法正在深入了解其在发育中的作用及其潜在机制。目前的研究表明，染色质是动态的，其结构和组蛋白修饰在发育过渡期间和响应细胞外信号发生全局变化。除了DNA甲基化和组蛋白修饰之外，重塑染色质的ATP依赖性酶是染色质结构和组装的重要控制者，并且是染色质动态性质的主要贡献者。有证据表明，这些染色质重塑酶在发育过程中具有指导性和程序性作用。特别有趣的是，ATP依赖性重塑分子的专门组装对于建立和维持细胞中的多能和多能状态至关重要。
New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues. In addition to DNA methylation and histone modification, ATP-dependent enzymes that remodel chromatin are important controllers of chromatin structure and assembly, and are major contributors to the dynamic nature of chromatin. Evidence is emerging that these chromatin-remodelling enzymes have instructive and programmatic roles during development. Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.
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