Different effectiveness of glucagon on the pacemaker activity and contractility in intact dog hearts and in isolated perfused right atria.
Different effectiveness of glucagon on the pacemaker activity and contractility in intact dog hearts and in isolated perfused right atria.
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胰高血糖素对完整狗心脏和离体灌注右心房的起搏器活性和收缩性的不同功效。
DOI：
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Chiba
中科院分区：
文献类型：
--
作者：
Y. Furukawa;K. Saegusa;Y. Ogiwara;S. Chiba
在一个孤立的右心房准备，这是交叉灌注与肝素化动脉血从支持狗，我们研究了胰高血糖素对心率和全身动脉血压的支持狗和心房率和收缩力的孤立灌注心房时，胰高血糖素被注入到颈外静脉的支持狗或到窦房结动脉的孤立心房准备。胰高血糖素（0.3至3微克/Kg i. v.）剂量依赖性地诱导心率显著增加和全身动脉血压小幅增加。在离体灌注的心房中，静脉注射胰高血糖素后1.5分钟，显著的正性变时性和轻微但显著的正性肌力作用以剂量依赖性方式诱发。普萘洛尔（1 mg/Kg i. v.）未显著改变这些积极作用。将胰高血糖素直接注射到离体心房的窦房结动脉中也诱导了明显的正性变时作用和小的正性变力作用，并呈剂量依赖性。静脉或动脉注射胰高血糖素的CF/HR比值（离体心房变力性/变时性）均小于0.7，远小于去甲肾上腺素的CF/HR比值（大于3.6）。这些结果证实，胰高血糖素静脉内或局部注射可产生显著的正性变时作用和较小的正性肌力作用，并表明胰高血糖素作为强心剂的有效性可能较低。
In an isolated right atrial preparation, which was cross-perfused with heparinized arterial blood from a support dog, we investigated the effects of glucagon on heart rate and systemic arterial blood pressure of the support dog and on atrial rate and contractile force of the isolated perfused atrium when glucagon was injected into the external jugular vein of the support dog or into the sinus node artery of the isolated atrial preparation. Glucagon (0.3 to 3 micrograms/Kg i.v.) to the support dog dose-dependently induced a prominent increase in heart rate and a small increase in systemic arterial blood pressure. In the isolated, perfused atrium, marked positive chronotropic and slight, but significant, positive inotropic effects were evoked dose-dependently 1.5 min after intravenous injection of glucagon. These positive effects were not altered significantly by propranolol (1 mg/Kg i.v.). Direct injection of glucagon into the sinus node artery of isolated atria also induced marked positive chronotropic and small positive inotropic effects dose-dependently. CF/HR ratios, inotropic effect per chronotropic effect in isolated atria, of glucagon injected intravenously or intraarterially were less than 0.7 and they were much less than those of norepinephrine (more than 3.6). These results confirm that glucagon injected intravenously or regionally produces a prominent positive chronotropic effect and a small positive inotropic effect and suggest that glucagon may be less effective as a cardiotonic agent.
胰高血糖素对狗迷走神经刺激的心脏变时性反应的影响。
DOI：
10.1152/ajpheart.1982.242.1.h7
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
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作者：
Stuesse,SL;Levy,MN;Zieske,H
通讯作者：
Zieske,H