Metal Cations in G-Quadruplex Folding and Stability.
Metal Cations in G-Quadruplex Folding and Stability.
复制标题
G-四链体折叠和稳定性中的金属阳离子。
DOI：
10.3389/fchem.2016.00038
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发表时间：
2016
影响因子：
5.5
通讯作者：
Basu S
中科院分区：
文献类型：
--
作者：
Bhattacharyya D;Mirihana Arachchilage G;Basu S
本文综述了金属阳离子与G-四链体（GQ）配位的结构和物理化学特征及其对GQ稳定性和构象的影响。G-四链体结构是由DNA和RNA形成的非规范二级结构。G-四链体调节广泛的重要生物化学过程。除了序列要求之外，GQ中一价阳离子的配位对于其形成是必不可少的，并且决定了GQ结构的稳定性和多态性。阳离子配位的性质、位置和动力学及其对整体GQ稳定性的影响取决于几个因素，如离子半径、水合能和鸟嘌呤与O 6的键合强度。细胞内单价阳离子浓度和局部离子浓度决定GQ的形成，并可能决定其调节作用。对一系列GQ使能序列的广泛的生物化学和生物物理学研究已经产生了最低限度的知识基础，该知识基础允许我们经常预测GQ在生理相关金属离子存在下的稳定性，然而，预测这种GQ的构象仍然不在该领域内。
This review is focused on the structural and physicochemical aspects of metal cation coordination to G-Quadruplexes (GQ) and their effects on GQ stability and conformation. G-quadruplex structures are non-canonical secondary structures formed by both DNA and RNA. G-quadruplexes regulate a wide range of important biochemical processes. Besides the sequence requirements, the coordination of monovalent cations in the GQ is essential for its formation and determines the stability and polymorphism of GQ structures. The nature, location, and dynamics of the cation coordination and their impact on the overall GQ stability are dependent on several factors such as the ionic radii, hydration energy, and the bonding strength to the O6 of guanines. The intracellular monovalent cation concentration and the localized ion concentrations determine the formation of GQs and can potentially dictate their regulatory roles. A wide range of biochemical and biophysical studies on an array of GQ enabling sequences have generated at a minimum the knowledge base that allows us to often predict the stability of GQs in the presence of the physiologically relevant metal ions, however, prediction of conformation of such GQs is still out of the realm.
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影响因子：
14.9
作者：
Bugaut A;Balasubramanian S
通讯作者：
Balasubramanian S
影响因子：
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通讯作者：
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作者：
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通讯作者：
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