Intermittent Androgen Suppression: Estimating Parameters for Individual Patients Based on Initial PSA Data in Response to Androgen Deprivation Therapy.
Intermittent Androgen Suppression: Estimating Parameters for Individual Patients Based on Initial PSA Data in Response to Androgen Deprivation Therapy.
复制标题
间歇性雄激素抑制：根据初始PSA数据响应雄激素剥夺疗法，对个别患者的参数进行估计。
DOI：
10.1371/journal.pone.0130372
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Aihara K
中科院分区：
文献类型：
--
作者：
Hirata Y;Morino K;Akakura K;Higano CS;Bruchovsky N;Gambol T;Hall S;Tanaka G;Aihara K
When a physician decides on a treatment and its schedule for a specific patient, information gained from prior patients and experience in the past is taken into account. A more objective way to make such treatment decisions based on actual data would be useful to the clinician. Although there are many mathematical models proposed for various diseases, so far there is no mathematical method that accomplishes optimization of the treatment schedule using the information gained from past patients or “rapid learning” technology. In an attempt to use this approach, we integrate the information gained from patients previously treated with intermittent androgen suppression (IAS) with that from a current patient by first fitting the time courses of clinical data observed from the previously treated patients, then constructing the prior information of the parameter values of the mathematical model, and finally, maximizing the posterior probability for the parameters of the current patient using the prior information. Although we used data from prostate cancer patients, the proposed method is general, and thus can be applied to other diseases once an appropriate mathematical model is established for that disease.
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影响因子：
1.9
作者：
Chitnis, Nakul;Cushing, J. M.;Hyman, J. M.
通讯作者：
Hyman, J. M.
影响因子：
3
作者：
Ideta, Aiko Miyamura;Tanaka, Gouhei;Aihara, Kazuyuki
通讯作者：
Aihara, Kazuyuki
影响因子：
6.2
作者：
Bruchovsky, Nicholas;Klotz, Laurence;Goldenberg, S. Larry
通讯作者：
Goldenberg, S. Larry
影响因子：
4.1
作者：
Komarova, SV;Smith, RJ;Wahl, LM
通讯作者：
Wahl, LM
影响因子：
2.7
作者：
MARDIA, KV
通讯作者：
MARDIA, KV