Leptin in the Placenta
Leptin in the Placenta
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胎盘中的瘦素
DOI：
--
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
P. Bischof
中科院分区：
文献类型：
--
作者：
D. Islami;P. Bischof
瘦素是一种多肽激素，其通过抑制食欲和刺激能量消耗而明显参与体重的调节。已知胎盘是循环瘦素的重要来源，并且也由人羊膜细胞的原代培养物产生的瘦素分泌到羊水中。瘦素浓度在整个人类妊娠期增加，在妊娠中期达到峰值，并保持高水平，直到分娩。另一方面，合体滋养细胞中瘦素mRNA丰度的下降是孕龄增加的共同特征。原位杂交表明，瘦素，OB-RL和OB-Rs mRNA转录本的表达仅限于内分泌活性的滋养层，因此合体滋养层覆盖胎盘绒毛。胎盘瘦素也被释放到胎儿循环中。瘦素是胎儿体重和生长的调节因子，也是母体和胎盘重量的重要调节因子。瘦素也可能与哺乳和新生儿生长的调节机制有关。在胎盘中，它可以自分泌的方式作为生长激素（GH）和生长因子的血管生成。在人类着床的侵袭阶段，瘦素已被证明在细胞滋养层细胞（CTB）的hCG产生的调节，整合素库的转换和刺激金属蛋白酶活性中发挥重要作用。瘦素的产生受白细胞介素（IL）-1β和17β-雌二醇的调节。瘦素作为一种自分泌/旁分泌调节人植入的入侵阶段的新的作用可能被提出。滋养层细胞瘦素可能是一种金属蛋白酶（MMP）分泌的诱导剂和整合素的表达的调节剂，赋予CTB的侵袭表型。本文综述了瘦素在胎盘中的作用，特别是在滋养层细胞的侵袭。
Leptin is a polypeptide hormone that is clearly involved in the regulation of body mass by suppressing appetite and stimulating energy expenditure. The placenta is known to be an important source of circulating leptin, and leptin, also produced by primary cultures of human amnion cells is secreted into the amniotic fluid. Leptin concentration increases throughout human gestation, peaks in the second trimester and remains high until parturition. On the other hand, a decline in leptin mRNA abundance in syncytiotrophoblast is a common feature of advancing gestational age. In situ hybridization has indicated that leptin, OB-RL, and OB-Rs mRNA transcript expression is limited to the endocrinologically active trophoblast, thus the syncytiotrophoblasts layer covering placental villi. Placental leptin is also released into the fetal circulation. Leptin is shown to act as a regulator of fetal weight and growth and as an important regulator of maternal and placental weight. Leptin may also be associated with mechanisms mediating lactation and neonatal growth. In the placenta, it could act in an autocrine way as a growth hormone (GH) and growth factor for angiogenesis. During the invasion phase of human implantation, leptin has been shown to play an important role in the regulation of hCG production by cytotrophoblastic cells (CTB), in the switching of the integrin repertoire and in stimulating metalloprotease activity. Leptin production is modulated by interleukin (IL)-1β and 17β-estradiol. A novel role for leptin as an autocrine/paracrine regulator of the invasion phase of human implantation may be proposed. Trophoblastic leptin could be an inducer of the secretion of metalloproteinases (MMP) and a modulator of the expression of integrins conferring an invasive phenotype to CTB. This review focuses on the role of leptin in the placenta and more specially in trophoblast invasion.
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DOI：
10.1093/humrep/12.10.2226
发表时间：
1997
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Antczak,M;VanBlerkom,J;Clark,A
通讯作者：
Clark,A
影响因子：
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Ahima, RS;Dushay, J;Flier, JS
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Flier, JS
雌激素对人胎盘滋养层低密度脂蛋白体外摄取的调节。
DOI：
10.1210/jcem.81.7.8675596
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Grimes,RW;Pepe,GJ;Albrecht,ED
通讯作者：
Albrecht,ED
DOI：
10.1073/pnas.93.16.8374
发表时间：
1996-08-06
影响因子：
11.1
作者：
Baumann, H;Morella, KK;Tartaglia, LA
通讯作者：
Tartaglia, LA
影响因子：
9.8
作者：
E. Sivan;P. Whittaker;D. Sinha;C. Homko;M. Lin;Reece Ea;G. Boden
通讯作者：
E. Sivan;P. Whittaker;D. Sinha;C. Homko;M. Lin;Reece Ea;G. Boden