Ventriculolumber perfusion of 3-[(4-amino-2-methyl-5-pyrimidinyl)- methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride for subarachnoid dissemination of gliomas
Ventriculolumber perfusion of 3-[(4-amino-2-methyl-5-pyrimidinyl)- methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride for subarachnoid dissemination of gliomas
复制标题
3-[(4-氨基-2-甲基-5-嘧啶基)-甲基]-1-(2-氯乙基)-1-亚硝基脲盐酸盐脑室灌注治疗神经胶质瘤的蛛网膜下腔播散
作者：
Y. Ushio;M. Kochi;I. Kitamura;J. Kuratsu
研究了脑室灌注盐酸阿昔洛韦(3-[(4-amino-2-methyl-5-pyrimidinyl)methyl-1-1(2-chloroethyl)-1-nitrosourea，ACNU)对脑胶质瘤蛛网膜下腔播散的毒性和疗效。21例患者(间变性胶质瘤6例，胶质母细胞瘤7例，髓母细胞瘤或PNET 8例)在被诊断为蛛网膜下腔播散时行ACNU脑室灌注。ACNU平均灌流10次，平均累积剂量95 mg。大多数患者接受全身化疗联合灌注治疗，部分患者接受放射治疗。间变性胶质瘤的有效率为17%，中位生存期为12个月，胶质母细胞瘤为29%和12个月，髓母细胞瘤和PNET为88%和25个月以上。7例高危患者在常规辅助治疗的基础上，对7例高危患者术后早期预防性脑室灌注ACNU。ACNU的平均灌注量和累积剂量分别为2.3次和21 mg。1例出现蛛网膜下腔播散，术后22个月死亡。另有6例患者术后中位数无转移，存活超过29个月。不良反应包括头痛4例，恶心呕吐5例，恢复期2例，右侧面肌无力1例，大便失禁3例，脑膜炎2例。除1例面肌无力外，其余均为暂时性不良反应。
The toxicity and therapeutic effect of the ventriculolumber perfussion of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl-1-1(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU) against subarachnoid dissemination of gliomas were studied. Twenty-one patients (6 patients with anaplastic glioma, 7 with glioblastoma and 8 with medulloblastoma or PNET) received ventriculolumber perfusion of ACNU when they were diagnosed as having subarachnoid dissemination. The course of perfusion and cumulative dose of ACNU was 10 times and 95 mg on average, respectively. Most of the patients received systemic chemotherapy in combination with perfusion therapy and some patients with radiotherapy. Response rate was 17% and median survival time after the diagnosis of dissemination was 12 months for anaplastic gliomas, 29% and 12 months for glioblastoma, and 88% and over 25 months for medulloblastoma and PNET. The ventriculolumber perfusion of ACNU was performed for prophylactic purpose in 7 patients with high risk at the early postoperative period in combination with conventional adjuvant therapy. The course of perfusion and cumulative dose of ACNU was 2.3 times and 21 mg on average, respectively. One patient developed subarachnoid dissemination and died 22 months after surgery. Other 6 patients survived without dissemination on median over 29 months after surgery. Side effects encountered were headache in 4 patients, nausea and vomiting in 5, a convalsion in 2, right facial weakness in 1, fecal incontinence in 3 and meningitis in 2. They were all temporary except for facial weakness occurred in one patient.These data suggest that the ventriculolumber perfusion of ACNU is a safe and useful in the treatment and prophylaxis against the subarachnoid dissemination of gliomas.
比格犬脑室内3-[(4-氨基-2-甲基-5-嘧啶基)乙基]-1-(2-氯乙基)-1-硝基脲和其他亚硝基脲的中枢神经系统毒性和脑脊液药代动力学。
影响因子：
11.2
作者：
Levin,VA;Byrd,D;Campbell,J;Giannini,DD;Borcich,JK;Davis,RL
通讯作者：
Davis,RL
DOI：
10.1159/000120013
发表时间：
1981
期刊：
Child's brain
影响因子：
--
作者：
Edwards,MS;Levin,VA;Seager,ML;Wilson,CB
通讯作者：
Wilson,CB