Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis.
Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis.
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DOI：
10.3389/fendo.2022.960351
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
视交叉上核(SCN)使生理节律与外部明暗周期同步，并根据光周期波动调节昼夜节律的动态。神经元网络拓扑结构的改变可能导致SCN对不同光周期的适应，导致神经元活动在长光周期(LP)中的相位分布比在短光周期(SP)中更宽。在SCN输出的调控下，糖皮质激素水平在短光周期内升高，这与疾病的发病高峰有关。SCN的潜在耦合机制以及SCN和HPA轴之间的相互作用尚未完全阐明。在这项工作中，我们提出了一个包含多细胞SCN隔室和HPA轴的数学模型来研究光周期变化下昼夜节律系统的特性。我们的模型预测，依赖概率的网络比依赖距离的网络更节能。通过子种群内力和子种群间力耦合SCN网络，我们发现振荡网络的稳健性与可塑性之间存在负相关。在SP状态下，HPA节律与SCN节律密切相关，并伴有促炎性高幅度糖皮质激素的变化。当同步不完全时，预测SCN网络的快速时态拓扑切换以增强同步。这些同步性和昼夜节律的变化可能控制着疾病发病率及其症状严重程度的季节变化。
The suprachiasmatic nucleus (SCN) synchronizes the physiological rhythms to the external light-dark cycle and tunes the dynamics of circadian rhythms to photoperiod fluctuations. Changes in the neuronal network topologies are suggested to cause adaptation of the SCN in different photoperiods, resulting in the broader phase distribution of neuron activities in long photoperiods (LP) compared to short photoperiods (SP). Regulated by the SCN output, the level of glucocorticoids is elevated in short photoperiod, which is associated with peak disease incidence. The underlying coupling mechanisms of the SCN and the interplay between the SCN and the HPA axis have yet to be fully elucidated. In this work, we propose a mathematical model including a multiple-cellular SCN compartment and the HPA axis to investigate the properties of the circadian timing system under photoperiod changes. Our model predicts that the probability-dependent network is more energy-efficient than the distance-dependent network. Coupling the SCN network by intra-subpopulation and inter-subpopulation forces, we identified the negative correlation between robustness and plasticity of the oscillatory network. The HPA rhythms were predicted to be strongly entrained to the SCN rhythms with a pro-inflammatory high-amplitude glucocorticoid profile under SP. The fast temporal topology switch of the SCN network was predicted to enhance synchronization when the synchronization is not complete. These synchronization and circadian dynamics alterations might govern the seasonal variation of disease incidence and its symptom severity.
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影响因子：
4
作者：
Dick TE;Molkov YI;Nieman G;Hsieh YH;Jacono FJ;Doyle J;Scheff JD;Calvano SE;Androulakis IP;An G;Vodovotz Y
通讯作者：
Vodovotz Y
影响因子：
4.3
作者：
Bodenstein C;Gosak M;Schuster S;Marhl M;Perc M
通讯作者：
Perc M
DOI：
10.1097/shk.0b013e318200032b
发表时间：
2011-03
期刊：
Shock (Augusta, Ga.)
影响因子：
--
作者：
Foteinou PT;Calvano SE;Lowry SF;Androulakis IP
通讯作者：
Androulakis IP
影响因子：
3.5
作者：
Geier, F;Becker-Weimann, S;Herzel, H
通讯作者：
Herzel, H
影响因子：
4.4
作者：
Gillespie, DT
通讯作者：
Gillespie, DT