Design of functional metalloproteins.
Design of functional metalloproteins.
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作者：
金属蛋白催化自然界中一些最困难但最重要的功能，如光合作用和水氧化。我们对金属蛋白如何工作的知识的最终测试是通过设计新的金属蛋白。这种设计不仅可以揭示天然金属蛋白及其变异研究中可能缺失的隐藏结构特征，而且还可以为生物技术和制药应用带来新的金属酶。虽然设计金属蛋白比设计非金属蛋白更具挑战性，但由于最近在计算生物学和结构生物学等领域的进展，这一领域取得了很大进展，特别是在功能设计方面。
Metalloproteins catalyze some of the most difficult and yet important functions in Nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is by designing novel metalloproteins. Such design can not only reveal hidden structural features that may be missing from studies of native metalloproteins and their variants, but also result in new metalloenzymes for biotechnological and pharmaceutical applications. While it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly toward functional design, thanks to recent progress in areas such as computational and structural biology.
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