Primary failure of eruption (PFE): a systematic review.
Primary failure of eruption (PFE): a systematic review.
复制标题
DOI：
10.1186/s13005-018-0163-7
复制
发表时间：
2018-03-15
影响因子：
3
通讯作者：
Jung S
中科院分区：
文献类型：
--
作者：
Hanisch M;Hanisch L;Kleinheinz J;Jung S
原发性萌出失败（PFE）是一种罕见的疾病，定义为不完全的牙齿萌出，尽管存在一个明确的萌出途径。在这种情况下，正畸挤压是不可行的，因为它会导致牙齿强直。据我们所知，除了Ahmad等人的研究（Eur J Orthod 28：535-540，2006）之外，没有研究系统地分析PFE的临床特征和相关因素。因此，本研究的目的是系统地评估当前文献（2006年至2017年），以获得关于PFE病因学，诊断，遗传学和治疗方案的新见解和发展。根据PRISMA指南，使用PubMed/Medline数据库对报告PFE的研究进行了系统检索。使用了以下术语：“原发性牙萌出失败”、“原发性牙萌出失败”、“牙萌出失败”和“PFE”。总体而言，识别出17篇报告314例患者临床数据的文章。在所有患者中，磨牙都受到影响。在81例报告的病例中，磨牙和前磨牙都受到PFE的影响。此外，38名患者的乳牙也受到影响。在27名患者中，没有家庭成员受到影响。在39名患者中观察到其他牙齿异常。共记录了与PFE相关的PTH 1 R基因的51种不同变体。PFE的特征是后牙咬合不正，特别是当两侧都受到影响时。如果患者受到PFE的影响，最近中牙齿远端的所有牙齿也会受到PFE的影响。乳牙也可能受到影响;然而，这并不一定会发生。如果患者被怀疑患有PFE，在任何正畸治疗之前，应建议进行PTH 1 R基因突变的基因检测，以避免关节强直。治疗方案取决于患者的年龄和临床情况，必须单独评估。
Primary failure of eruption (PFE) is a rare disease defined as incomplete tooth eruption despite the presence of a clear eruption pathway. Orthodontic extrusion is not feasible in this case because it results in ankylosis of teeth. To the best of our knowledge, besides the study of Ahmad et al. (Eur J Orthod 28:535-540, 2006), no study has systematically analysed the clinical features of and factors associated with PFE. Therefore, the aim of this study was to systematically evaluate the current literature (from 2006 to 2017) for new insights and developments on the aetiology, diagnosis, genetics, and treatment options of PFE. Following the PRISMA guidelines, a systematic search was performed using the PubMed/Medline database for studies reporting on PFE. The following terms were used: “primary failure of tooth eruption”, “primary failure of eruption”, “tooth eruption failure”, and “PFE”. Overall, 17 articles reporting clinical data of 314 patients were identified. In all patients, the molars were affected. In 81 reported cases, both the molars and the premolars were affected by PFE. Further, 38 patients’ primary teeth were also affected. In 27 patients, no family members were affected. Additional dental anomalies were observed in 39 patients. A total of 51 different variants of the PTH1R gene associated with PFE were recorded. Infraocclusion of the posterior teeth, especially if both sides are affected, is the hallmark of PFE. If a patient is affected by PFE, all teeth distal to the most mesial tooth are also affected by PFE. Primary teeth can also be impacted; however, this may not necessarily occur. If a patient is suspected of having PFE, a genetic test for mutation in the PTH1R gene should be recommended prior to any orthodontic treatment to avoid ankylosis. Treatment options depend on the patient’s age and the clinical situation, and they must be evaluated individually.
登录
查看更多内容
影响因子：
0.9
作者：
Jain, Upendra;Kallury, Amitabh;Bharti, Harsh Vibhor
通讯作者：
Bharti, Harsh Vibhor
DOI：
10.1007/s00056-014-0215-y
发表时间：
2014-05-01
影响因子：
1.7
作者：
Pilz, Peter;Meyer-Marcotty, Philipp;Stellzig-Eisenhauer, Angelika
通讯作者：
Stellzig-Eisenhauer, Angelika
影响因子：
2.2
作者：
Proff, Peter;Bayerlein, Thomas;Gedrange, Tomas
通讯作者：
Gedrange, Tomas
影响因子：
1.5
作者：
Cohen-Levy, Julia
通讯作者：
Cohen-Levy, Julia
影响因子：
3.3
作者：
RAGHOEBAR, GM;BOERING, G;VISSINK, A
通讯作者：
VISSINK, A