Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells.
Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells.
复制标题
脂肪组织树突状细胞通过促进 Th17 细胞的生成来增强炎症
DOI：
10.1371/journal.pone.0092450
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Chen Y;Tian J;Tian X;Tang X;Rui K;Tong J;Lu L;Xu H;Wang S
背景肥胖已成为全球性的公共卫生挑战。据报道，肥胖与慢性炎症有关。方法/主要发现在我们的研究中，我们发现在小鼠脂肪组织中存在一种新的CD 11 c+树突状细胞亚群，该亚群为未成熟表型。此外，与瘦对照相比，高脂饮食（HFD）小鼠脂肪组织中的CD 11 c + DC和CD 4 +IL-17+T细胞的数量更高。脂肪组织来源的树突状细胞（ATDC）显示较低水平的CD 40，CD 80，CD 86，MHCI和MHCII表达比脾DC（SPDC）。ATDC分泌IL-6、TGF-β和IL-23的水平高于ATDC。结论：脂肪组织中存在CD 11 c +DCs，其表型不成熟，但具有促炎功能。
BackgroundObesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive.Methodology/Principal FindingsIn our study, we found a novel CD11c+dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared to the lean controls, the number of CD11c+DCs and CD4+IL-17+T cells were higher in adipose tissue of high fat diet (HFD) mice. Adipose tissues derived dendritic cells (ATDCs) displayed lower levels of CD40, CD80, CD86, MHCI and MHCII expression than splenic DCs (SPDCs). However, ATDCs showed higher levels of IL-6, TGF-β and IL-23 secretion. Moreover, ourin vitroexperiments demonstrated that ATDCs were capable of promoting Th17 cell generation.Conclusions/SignificanceOur results indicate the existence of CD11c+DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function.
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