Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function.
Interactive effects of locus coeruleus structure and catecholamine synthesis capacity on cognitive function.
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DOI：
10.3389/fnagi.2023.1236335
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发表时间：
2023
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
蓝斑 (LC) 产生儿茶酚胺（去甲肾上腺素和多巴胺），与广泛的认知功能（包括注意力和执行功能）有关。磁共振成像（MRI）方法的最新进展使得液晶结构的可视化和量化成为可能。鉴于 LC 在认知中的作用以及与当前精神病理学和神经退行性疾病模型的相关性，针对 LC 的人类研究已呈爆炸式增长。然而，目前尚不清楚 LC 结构在多大程度上反映了潜在的儿茶酚胺功能，以及 LC 结构和神经化学功能如何与认知表现共同相关。对 19 名参与者的 LC 结构 MRI 测量和使用 [18F] 氟间酪氨酸 ([18F]FMT) 正电子发射断层扫描 (PET) 评估的儿茶酚胺合成能力测量进行了偏最小二乘相关 (PLSC) 分析。我们发现 LC-MRI 和 LC-[18F]FMT 测量之间对于 LC 的头端、中部或尾端部分没有直接关联。我们发现 LC 神经影像学测量与神经心理学表现之间存在显着关联，这种关联是由 LC 的喙部和中部部分驱动的，这与 LC 皮质投射模式一致。具体来说，与执行功能和处理速度的关联源自LC结构以及LC结构和儿茶酚胺合成能力之间的相互作用的贡献。这些发现为 LC MRI 和 PET 测量提供独特信息提供了可能性，并表明它们的联合使用可能会增加对小样本中大脑行为关联的敏感性。
The locus coeruleus (LC) produces catecholamines (norepinephrine and dopamine) and is implicated in a broad range of cognitive functions including attention and executive function. Recent advancements in magnetic resonance imaging (MRI) approaches allow for the visualization and quantification of LC structure. Human research focused on the LC has since exploded given the LC’s role in cognition and relevance to current models of psychopathology and neurodegenerative disease. However, it is unclear to what extent LC structure reflects underlying catecholamine function, and how LC structure and neurochemical function are collectively associated with cognitive performance. A partial least squares correlation (PLSC) analysis was applied to 19 participants’ LC structural MRI measures and catecholamine synthesis capacity measures assessed using [18F]Fluoro-m-tyrosine ([18F]FMT) positron emission tomography (PET). We found no direct association between LC-MRI and LC-[18F]FMT measures for rostral, middle, or caudal portions of the LC. We found significant associations between LC neuroimaging measures and neuropsychological performance that were driven by rostral and middle portions of the LC, which is in line with LC cortical projection patterns. Specifically, associations with executive function and processing speed arose from contributions of both LC structure and interactions between LC structure and catecholamine synthesis capacity. These findings leave open the possibility that LC MRI and PET measures contribute unique information and suggest that their conjoint use may increase sensitivity to brain-behavior associations in small samples.
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3.3
作者：
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DOI：
10.1097/nen.0b013e318232a379
发表时间：
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影响因子：
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