Functional Coupling of the Locus Coeruleus Is Linked to Successful Cognitive Control.
Functional Coupling of the Locus Coeruleus Is Linked to Successful Cognitive Control.
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DOI：
10.3390/brainsci12030305
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发表时间：
2022-02-24
期刊：
影响因子：
3.3
通讯作者：
Ruff CC
中科院分区：
文献类型：
--
作者：
Grueschow M;Kleim B;Ruff CC
蓝斑(LC)是一种脑干结构，在哺乳动物的大脑中发送广泛的传出投射。LC是去甲肾上腺素(NE)的主要来源，去甲肾上腺素(NE)是一种调节性神经递质，对唤醒、注意力和认知控制等基本大脑功能至关重要。LC-NE的这种作用传统上被认为不能反映额顶网络或纹状体的功能影响，但最近啮齿类动物大脑的化学遗传操作的进展挑战了这一概念。然而，LC-NE与人脑这些区域的功能连接的证据令人惊讶地稀少。在这里，我们弥合这一差距。使用已建立的情绪跳跃任务，我们直接比较了需要反应冲突控制的试验和不需要反应冲突控制的试验，但在视觉刺激特性、反应方式和控制瞳孔放大差异方面两种试验类型都匹配。我们发现，在需要反应冲突控制的试验中，LC-NE与顶叶皮质和纹状体区域的功能耦合显著增强。至关重要的是，这种功能耦合的强度与冲突解决所引起的个体反应时差直接相关。我们的数据与啮齿动物最近的发现一致，并强调了在人类和非人类神经生理学之间融合证据的重要性，以进一步了解支持健康和疾病中适应和不适应行为的神经系统。
The locus coeruleus (LC) is a brainstem structure that sends widespread efferent projections throughout the mammalian brain. The LC constitutes the major source of noradrenaline (NE), a modulatory neurotransmitter that is crucial for fundamental brain functions such as arousal, attention, and cognitive control. This role of the LC-NE is traditionally not believed to reflect functional influences on the frontoparietal network or the striatum, but recent advances in chemogenetic manipulations of the rodent brain have challenged this notion. However, demonstrations of LC-NE functional connectivity with these areas in the human brain are surprisingly sparse. Here, we close this gap. Using an established emotional stroop task, we directly compared trials requiring response conflict control with trials that did not require this, but were matched for visual stimulus properties, response modality, and controlled for pupil dilation differences across both trial types. We found that LC-NE functional coupling with the parietal cortex and regions of the striatum is substantially enhanced during trials requiring response conflict control. Crucially, the strength of this functional coupling was directly related to individual reaction time differences incurred by conflict resolution. Our data concur with recent rodent findings and highlight the importance of converging evidence between human and nonhuman neurophysiology to further understand the neural systems supporting adaptive and maladaptive behavior in health and disease.
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影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ
DOI：
10.1017/s1355617799544020
发表时间：
1999-05-01
影响因子：
2.6
作者：
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4.3
作者：
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
2.9
作者：
ARNSTEN, AFT;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS