[18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients.
[18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients.
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DOI：
10.1016/j.radonc.2012.04.003
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Guerrero T
中科院分区：
文献类型：
--
作者：
McCurdy MR;Castillo R;Martinez J;Al Hallack MN;Lichter J;Zouain N;Guerrero T
定量肺癌患者放疗后2-[18 F]-氟-2-脱氧葡萄糖（FDG）肺摄取的剂量-反应，并确定其与放射性肺炎症状的关系。对24例接受胸部放疗的肺癌患者的数据进行了评价，这些患者在放疗结束后4 - 12周接受了再分期PET/CT成像。通过治疗后重新分级PET/CT记录了他们的辐射剂量分布。使用直方图分析，体素平均FDG-PET摄取与辐射剂量得到每一个情况下，进行线性回归。所得斜率，肺代谢辐射反应（PMRR），用于表征剂量反应。使用通用毒性标准第3版对临床肺毒性症状进行评分。受试者工作特征（ROC）曲线用于确定FDG摄取水平与剂量、MLD、V5、V10、V20和V30的关系，这些参数可以最好地预测有症状和无症状患者。放疗完成和FDG-PET成像之间的中位时间为59天（范围，26-70天）。接受0-5戈伊治疗的肺的平均SUV中位数为1.00（范围，0.37-1.48），5-10戈伊为1.01（范围，0.37-1.77），10 - 20戈伊为1.04（0.42-1.53），> 20戈伊为1.29（范围，0.41-8.01）。使用0戈伊至最大剂量减去10戈伊的剂量范围，放射剂量和每个病例的标准化FDG摄取的分层线性回归模型发现与线性模型的拟合良好。腹膜炎评分为：13例为0级，5例为1级，6例为2级，无3、4或5级。使用0.017的PMRR阈值产生0.67的相关真阳性率和0.15的假阳性率，平均误差为30%。57.6的V5阈值给出了0.67的相关真阳性率和0.05的假阳性率，平均误差为20%。根据治疗后FDG-PET/CT成像评价代谢性放射性肺炎的剂量反应。统计建模发现线性关系。FDG摄取剂量反应和V5与有症状的放射性肺炎相关。
To quantify the post-radiotherapy 2-[18F]-fluoro-2-deoxyglucose (FDG) pulmonary uptake dose-response in lung cancer patients and determine its relationship with radiation pneumonitis symptoms. The data from 24 patients treated for lung cancer with thoracic radiotherapy who received restaging PET/CT imaging between 4 and 12 weeks after radiotherapy completion were evaluated. Their radiation dose distribution was registered with the post-treatment restaging PET/CT. Using histogram analysis, the voxel average FDG-PET uptake versus radiation dose was obtained for each case and linear regression was performed. The resulting slope, the pulmonary metabolic radiation response (PMRR), was used to characterize the dose-response. The Common Toxicity Criteria version 3 was used to score clinical pulmonary toxicity symptoms. Receiver operating characteristic (ROC) curves were used to determine the level of FDG uptake v. dose, MLD, V5, V10, V20, and V30 that can best predict symptomatic and asymptomatic patients. The median time between radiotherapy completion and FDG-PET imaging was 59 days (range, 26–70 days). The median of the mean SUV from lung that received 0–5 Gy was 1.00 (range, 0.37–1.48), 5–10 Gy was 1.01 (range, 0.37–1.77), 10 –20 Gy was 1.04 (0.42–1.53), and > 20 Gy was 1.29 (range, 0.41–8.01). Using the dose range of 0 Gy to the maximum dose minus 10 Gy, hierarchical linear regression model of the radiation dose and normalized FDG uptake per case found an adequate fit with the linear model. Pneumonitis scores were: Grade 0 for 13, Grade 1 for 5, Grade 2 for 6, and Grade 3, 4 or 5 for none. Using a PMRR threshold of 0.017 yields an associated true positive rate of 0.67 and false positive rate of 0.15 with average error of 30%. A V5 threshold of 57.6 gives an associated true positive rate of 0.67 and false positive rate of 0.05 with a 20% average error. The metabolic radiation pneumonitis dose response was evaluated from post-treatment FDG-PET/CT imaging. Statistical modeling found a linear relationship. The FDG uptake dose response and V5 correlated with symptomatic radiation pneumonitis.
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影响因子：
5
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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DOI：
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影响因子：
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