The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial.
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial.
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DOI：
10.1186/s12979-022-00304-w
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发表时间：
2022-10-17
影响因子：
7.9
通讯作者：
Xiao, Haipeng
中科院分区：
文献类型：
--
作者：
Liu, Yihao;Zhang, Hui;Yuan, Gang;Yao, Mi;Li, Bin;Chen, Jianying;Fan, Yuling;Mo, Ruohui;Lai, Fenghua;Chen, Xinwen;Li, Mengyuan;Chen, Binfeng;Lord, Janet M.;Peng, Sui;Cheng, KarKeung;Xiao, Haipeng
接种疫苗对预防流感很重要，但免疫反应会随着年龄的增长而减弱。免疫系统的昼夜节律性质表明，调整疫苗接种时间可能会提供改善免疫原性的机会。我们之前在伯明翰进行的群集试验表明，老年人流感疫苗中某些菌株的上午和下午接种存在差异。这种影响是否也出现在免疫力受损可能性较小的年轻人群中尚不清楚。因此，我们在广州进行了一项基于个体的随机对照试验，以检验老年人上午接种流感疫苗比下午接种流感疫苗诱导更强的免疫应答的假设。我们纳入了中年成年人，以确定这种影响是否也出现在较年轻的年龄组。在随机分配的418名参与者中，389名（93.1%，191名50-60岁的中年人和198名65-75岁的老年人）接受了随访。总体而言，抗体滴度之间没有显著差异上午vs下午接种后（几何平均值/95% CI）甲型H1N1流感病毒：39.9（32.4，49.1）vs. 33.0（26.7，40.7），p = 0.178; A/H3N2：92.2（82.8，102.7）vs. 82.0（73.8，91.2），p = 0.091; B：15.8（13.9，17.9）vs. 14.4（12.8，16.3），p = 0.092）。然而，在预先指定的亚组分析中，65-75岁亚组中上午接种疫苗与下午接种疫苗的接种后滴度为（A/H1N1）：49.5（36.7，66.6）与32.9（24.7，43.9），p = 0.050;（A/H3N2）：93.5（80.6，108.5）vs. 73.1（62.9，84.9），p = 0.021;（B）：16.6（13.8，20.1）vs. 14.4（12.3，17.0），p = 0.095。在女性中，上午与下午接种疫苗的抗体滴度为（A/H1N1）：46.9（35.6，61.8）与31.1（23.8，40.7），p = 0.030;（A/H3 N2）：96.0（83.5，110.3）与84.7（74.4，96.5），p = 0.176;（B）：14.8（12.7，17.3）与13.0（11.3，14.9），p = 0.061。在50-60岁亚组和男性中，上午和下午接种无显著差异。早晨接种可增强65岁以上成人和女性对流感疫苗的免疫原性。在大多数卫生系统中，修改疫苗接种计划以在早晨为老年人接种疫苗的干预措施简单、免费且可行。在线版本包含补充材料，可通过10.1186/s12979-022-00304-w获得。
Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial in Birmingham suggested differences between morning and afternoon vaccination for some strains in the influenza vaccine in older adults. Whether this effect is also seen in a younger age group with less likelihood of compromised immunity is unknown. We therefore conducted an individual-based randomized controlled trial in Guangzhou to test the hypothesis that influenza vaccination in the morning induces a stronger immune response in older adults than afternoon vaccination. We included adults in middle age to determine if the effect was also seen in younger age groups. Of the 418 participants randomised, 389 (93.1%, 191 middle-aged adults aged 50–60 years and 198 older adults aged 65–75 years) were followed up. Overall, there was no significant difference between the antibody titers (geometric mean /95% CI) after morning vs afternoon vaccination (A/H1N1: 39.9 (32.4, 49.1) vs. 33.0 (26.7, 40.7), p = 0.178; A/H3N2: 92.2 (82.8, 102.7) vs. 82.0 (73.8, 91.2), p = 0.091; B: 15.8 (13.9, 17.9) vs. 14.4 (12.8, 16.3), p = 0.092), respectively. However, in pre-specified subgroup analyses, post-vaccination titers for morning versus afternoon vaccination in the 65–75 years subgroup were (A/H1N1): 49.5 (36.7, 66.6) vs. 32.9 (24.7, 43.9), p = 0.050; (A/H3N2): 93.5 (80.6, 108.5) vs. 73.1 (62.9, 84.9), p = 0.021; (B): 16.6 (13.8, 20.1) vs. 14.4 (12.3, 17.0), p = 0.095, respectively. Among females, antibody titers for morning versus afternoon vaccination were (A/H1N1): 46.9 (35.6, 61.8) vs. 31.1 (23.8, 40.7), p = 0.030; (A/H3N2): 96.0 (83.5, 110.3) vs. 84.7 (74.4, 96.5), p = 0.176; (B): 14.8 (12.7, 17.3) vs. 13.0 (11.3, 14.9), p = 0.061, respectively. In the 50–60 years old subgroup and males, there were no significant differences between morning and afternoon vaccination. Morning vaccination may enhance the immunogenicity to influenza vaccine in adults aged over 65 and women. An intervention to modify vaccination programs to vaccinate older individuals in the morning is simple, cost free and feasible in most health systems. The online version contains supplementary material available at 10.1186/s12979-022-00304-w.
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淋巴细胞昼夜节律的时钟控制淋巴结运输和适应性免疫反应。
影响因子：
32.4
作者：
Druzd D;Matveeva O;Ince L;Harrison U;He W;Schmal C;Herzel H;Tsang AH;Kawakami N;Leliavski A;Uhl O;Yao L;Sander LE;Chen CS;Kraus K;de Juan A;Hergenhan SM;Ehlers M;Koletzko B;Haas R;Solbach W;Oster H;Scheiermann C
通讯作者：
Scheiermann C
影响因子：
120.7
作者：
Jackson, Lisa A.;Campbell, James D.;Bellamy, Abbie R.
通讯作者：
Bellamy, Abbie R.
影响因子：
9.2
作者：
Potluri, Tanvi;Fink, Ashley L.;Klein, Sabra L.
通讯作者：
Klein, Sabra L.
DOI：
10.1073/pnas.1800431115
发表时间：
2018-09-04
影响因子：
11.1
作者：
Early JO;Menon D;Wyse CA;Cervantes-Silva MP;Zaslona Z;Carroll RG;Palsson-McDermott EM;Angiari S;Ryan DG;Corcoran SE;Timmons G;Geiger SS;Fitzpatrick DJ;O'Connell D;Xavier RJ;Hokamp K;O'Neill LAJ;Curtis AM
通讯作者：
Curtis AM
影响因子：
7.3
作者：
Sánchez-de Prada L;Ortiz de Lejarazu-Leonardo R;Castrodeza-Sanz J;Tamayo-Gómez E;Eiros-Bouza JM;Sanz-Muñoz I
通讯作者：
Sanz-Muñoz I