Sex, gonads, sex hormones and histamine-stimulated gastric acid and serum pepsinogen
Sex, gonads, sex hormones and histamine-stimulated gastric acid and serum pepsinogen
复制标题
性、性腺、性激素和组胺刺激的胃酸和血清胃蛋白酶原
作者：
J. H. Baron
摘要：目的与设计：由于男性比女性分泌更多的酸，并且十二指肠溃疡在男性中更常见，并且在怀孕期间和使用己烯雌酚后缓解，因此在狗中研究了性别、性激素和性腺的影响。材料：对患有慢性胃瘘的4只雄性和4只雌性灰狗进行了测试。方法：静脉输注组胺1-16 μg/min，并在每次60 min输注的最后30 min测量平台酸排出量。然后取出性腺并重新检测分泌物。然后每天给切除卵巢的狗给予己烯雌酚2 mg（±孕酮25 mg i.m.）。每周三次），并且卵巢切除的母犬每周两次i.m.结果：犬和母犬的次最大和最大酸排出量（和血清胃蛋白酶原）相似，并与体重相关。性腺切除术没有改变这些功能，也没有给予异性激素1-12个月。结论：在狗中，在大鼠中，可能在人中，组胺刺激的胃酸分泌是身体大小的函数，而不是性别。
Abstract.Objective and Design: The effects of sex, sex hormones and gonads were studied in dogs because men secrete more acid than woman and duodenal ulcer is commoner in men and remits in pregnancy and after stilboestrol.¶Material: Four male and 4 female greyhounds with chronic gastric fistulas were tested.¶Methods: Histamine was infused i.v. 1–16 μg/min and plateau acid output measured in the last 30 min of each 60 min infusion.¶Treatment: The gonads were then removed and secretion retested. The orchidectomised dogs were then given stilboestrol 2 mg daily (±progesterone 25 mg i.m. three times a week) and the oophorectomised bitches given testosterone propionate 25 mg twice weekly i.m. and secretion again retested.¶Results: Submaximal and maximal acid outputs (and serum pepsinogen) of dogs and bitches were similar and correlated with body weight. Gonadectomy did not alter these functions nor did hormones of the opposite sex given for 1–12 months.¶Conclusions: In the dog, as in the rat, and probably in man, histamine-stimulated gastric acid output is a function of body size and not of sex.
胃内酸度和血浆胃泌素浓度是否存在性别相关差异？
DOI：
10.1042/cs0820595
发表时间：
1992
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Hobsley,M
通讯作者：
Hobsley,M