Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: a pilot study.
Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: a pilot study.
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DOI：
10.1016/j.bone.2011.08.032
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发表时间：
2012-01
期刊：
影响因子：
4.1
通讯作者：
Affuso O
中科院分区：
文献类型：
--
作者：
Casazza K;Hanks LJ;Hidalgo B;Hu HH;Affuso O
机械刺激对于最大化骨矿化的几何特性是必要的，有助于长期强度。骨中矿化量与骨髓脂肪组织体积呈负相关，这种关系被认为是骨折的独立预测因子。体力活动是影响矿化和骨髓容量的外在因素，发挥不断增长的骨骼的许可能力，以实现其全部遗传潜力。由于几何形状和形状决定过程主要表现在线性生长期，因此伴随幼儿期（3至6岁）的加速结构变化可能对终身骨骼健康产生深远影响。这项初步研究的目的是确定对幼儿进行短期体力活动干预是否会增加骨的几何特性。每周三天，干预组（n=10）参加了30分钟的中等强度的身体活动，如跳跃，跳跃和跑步，以及伸展活动，而对照组（n=10）在10周的干预期间进行日常活动。分别在基线和10周后通过磁共振成像和双能X线吸收法评估股骨骨髓脂肪组织体积和全身成分。虽然在10周后，没有观察到组间差异，但在参与体力活动干预的患者中观察到股骨髓脂肪组织体积显著减少。我们的研究结果表明，体力活动可能通过对股骨骨髓脂肪组织的拮抗作用和对骨矿化的长期激动作用来改善骨质量。
Mechanical stimulation is necessary for maximization of geometrical properties of bone mineralization contributing to long-term strength. The amount of mineralization in bones has been reciprocally related to volume of bone marrow adipose tissue and this relationship is suggested to be an independent predictor of fracture. Physical activity represents an extrinsic factor that impacts both mineralization and marrow volume exerting permissive capacity of the growing skeleton to achieve its full genetic potential. Because geometry- and shape-determining processes primarily manifest during the linear growth period, the accelerated structural changes accompanying early childhood (ages 3 to 6 y) may have profound impact on lifelong bone health. The objective of this pilot study was to determine if a short-term physical activity intervention in young children would result in augmentation of geometric properties of bone. Three days per week the intervention group (n=10) participated in 30 minutes of moderate intensity physical activity, such as jumping, hopping and running, and stretching activities, whereas controls (n=10) underwent usual activities during the 10-week intervention period. Femoral bone marrow adipose tissue volume and total body composition were assessed by magnetic resonance imaging and dual-energy X-ray absorptiometry, respectively, at baseline and after ten weeks. Although after 10-weeks, intergroup differences were not observed, a significant decrease in femoral marrow adipose tissue volume was observed in those participating in physical activity intervention. Our findings suggest physical activity may improve bone quality via antagonistic effects on femoral bone marrow adipose tissue and possibly long-term agonistic effects on bone mineralization.
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影响因子：
6.2
作者：
Kirmani, Salman;Christen, David;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
影响因子：
6.2
作者：
Qiu, Weimin;Andersen, Tom E.;Kassem, Moustapha
通讯作者：
Kassem, Moustapha
影响因子：
6.2
作者：
Macdonald, Heather M.;Kontulainen, Saija A.;McKay, Heather A.
通讯作者：
McKay, Heather A.
DOI：
10.1111/j.1467-789x.2010.00824.x
发表时间：
2011-05
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Hu HH;Nayak KS;Goran MI
通讯作者：
Goran MI
影响因子：
18.4
作者：
Cooper, D. M. L.;Ahamed, Y.;McKay, H. A.
通讯作者：
McKay, H. A.