Analogue pattern matching in a dendritic spine model based on phosphorylation of potassium channels
Analogue pattern matching in a dendritic spine model based on phosphorylation of potassium channels
复制标题
基于钾通道磷酸化的树突棘模型中的模拟模式匹配
DOI：
10.1088/0954-898x_11_4_303
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
K. Blackwell
中科院分区：
文献类型：
--
作者：
Keun;K. Blackwell
Modification of potassium channels by protein phosphorylation has been shown to play a role in learning and memory. If such memory storage machinery were part of dendritic spines, then a set of spines could act as an ‘analogue pattern matching’ device by learning a repeatedly presented pattern of synaptic activation. In this study, the plausibility of such analogue pattern matching is investigated in a detailed circuit model of a set of spines attached to a dendritic branch. Each spine head contains an AMPA synaptic channel in parallel with a calcium-dependent potassium channel whose sensitivity depends on its phosphorylation state. Repeated presentation of synaptic activity results in calcium activation of protein kinases and subsequent channel phosphorylation. Simulations demonstrate that signal strength is greatest when the synaptic input pattern is equal to the previously learned pattern, and smaller when components of the synaptic input pattern are either smaller or larger than corresponding components of the previously learned pattern. Therefore, our results indicate that dendritic spines may act as an analogue pattern matching device, and suggest that modulation of potassium channels by protein kinases may mediate neuronal pattern recognition.
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DOI：
--
发表时间：
1984-09
期刊：
The Journal of experimental biology
影响因子：
--
作者：
R. Hawkins
通讯作者：
R. Hawkins
影响因子：
56.9
作者：
LEMASSON, G;MARDER, E;ABBOTT, LF
通讯作者：
ABBOTT, LF
海兔感觉神经元中蛋白激酶 C 激活引起的兴奋性的长期变化。
DOI：
10.1152/jn.1998.79.3.1210
发表时间：
1998
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Manseau,F;Sossin,WS;Castellucci,VF
通讯作者：
Castellucci,VF
影响因子：
2.5
作者：
Cook, EP;Johnston, D
通讯作者：
Johnston, D
树突电压和钙门控通道放大了浦肯野细胞模型中突触后反应的变异性。
DOI：
10.1152/jn.1998.80.2.504
发表时间：
1998
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
DeSchutter,E
通讯作者：
DeSchutter,E