Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.
Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.
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DOI：
10.1016/j.biopsych.2022.01.016
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发表时间：
2022-06-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
杏仁核在焦虑和自闭症谱系障碍中都有广泛的关联。然而，目前还没有研究调查自闭症患者并发焦虑与纵向杏仁核发育之间的关系。在这里，作者描述了自闭症儿童在童年时期的杏仁核发育，有和没有传统的DSM形式的焦虑和焦虑与自闭症明显相关。对71名自闭症儿童和55名典型发育（TD）儿童（~ 2.5-12岁，411个时间点）进行纵向磁共振成像扫描。传统的DSM焦虑和与自闭症明显相关的焦虑在研究时间4（~ 8-12年）使用针对自闭症的诊断访谈进行评估：焦虑症访谈时间表- iv与自闭症谱系附录。采用混合效应模型检验研究时间1（3.18岁）和4（11.36岁）的组间差异以及有无DSM或自闭症明显焦虑的自闭症儿童与TD儿童左右杏仁核体积的发育差异（按年龄组相互作用）。自闭症伴DSM焦虑儿童的右侧杏仁核体积在学习时间1（增加5.10%）和学习时间4（增加6.11%）均显著大于TD儿童。有自闭症明显焦虑的自闭症儿童右侧杏仁核的生长速度明显慢于TD组、无焦虑组和自闭症- dsm焦虑组，且第4时刻右侧杏仁核体积小于无焦虑组（减少- 8.13%）和自闭症- dsm焦虑组（减少- 12.05%）。DSM和自闭症之间不同的杏仁核体积和发育轨迹——不同形式的焦虑——表明自闭症中这些共同发生的常见疾病有不同的生物学基础。
The amygdala is widely implicated in both anxiety and autism spectrum disorder. However, no studies have investigated the relationship between co-occurring anxiety and longitudinal amygdala development in autism. Here, the authors characterize amygdala development across childhood in autistic children with and without traditional DSM forms of anxiety and anxieties distinctly related to autism. Longitudinal magnetic resonance imaging scans were acquired at up to four time points for 71 autistic and 55 typically developing (TD) children (∼2.5–12 years, 411 time points). Traditional DSM anxiety and anxieties distinctly related to autism were assessed at study time 4 (∼8–12 years) using a diagnostic interview tailored to autism: the Anxiety Disorders Interview Schedule-IV with the Autism Spectrum Addendum. Mixed-effects models were used to test group differences at study time 1 (3.18 years) and time 4 (11.36 years) and developmental differences (age-by-group interactions) in right and left amygdala volume between autistic children with and without DSM or autism-distinct anxieties and TD children. Autistic children with DSM anxiety had significantly larger right amygdala volumes than TD children at both study time 1 (5.10% increase) and time 4 (6.11% increase). Autistic children with autism-distinct anxieties had significantly slower right amygdala growth than TD, autism–no anxiety, and autism–DSM anxiety groups and smaller right amygdala volumes at time 4 than the autism–no anxiety (−8.13% decrease) and autism–DSM anxiety (−12.05% decrease) groups. Disparate amygdala volumes and developmental trajectories between DSM and autism-distinct forms of anxiety suggest different biological underpinnings for these common, co-occurring conditions in autism.
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影响因子：
8.2
作者：
Hennessey T;Andari E;Rainnie DG
通讯作者：
Rainnie DG
影响因子：
3.3
作者：
Bartolotti J;Sweeney JA;Mosconi MW
通讯作者：
Mosconi MW
影响因子：
16.2
作者：
Duvarci S;Pare D
通讯作者：
Pare D
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
5.7
作者：
Hung, Yuwen;Smith, Mary Lou;Taylor, Margot J.
通讯作者：
Taylor, Margot J.