Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites.
Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites.
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DOI：
10.3390/ma2041929
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Skrtic D
中科院分区：
文献类型：
--
作者：
O'Donnell JN;Schumacher GE;Antonucci JM;Skrtic D
我们在过去十年中对基于无定形磷酸钙 (ACP) 的材料的研究已经产生了生物活性聚合物复合材料，能够保护牙齿免于脱矿，甚至再生丢失的牙齿矿物质。这些 ACP 复合材料的抗龋齿/再矿化潜力源于它们在暴露于口腔环境时以持续方式释放足够水平的矿物质形成钙和磷酸盐离子的倾向，以促进稳定的磷灰石牙齿矿物质的形成。然而，这些实验材料的 ACP 填料/树脂基体内聚力不够理想、过度聚合收缩和吸水可能对其物理化学和机械性能产生不利影响，并最终限制其使用寿命。本研究证明了用于形成复合材料基体相的甲基丙烯酸酯单体的化学结构和组成对共聚物和复合材料的乙烯基转化率（DVC）和吸水性以及复合材料中矿物离子释放的影响。在填料合成过程中通过从头开始引入阳离子和/或聚合物来对 ACP 表面进行改性未能产生机械改进的复合材料。然而，通过 ACP 填料的硅烷化和/或研磨，可以在不影响其再矿化潜力的情况下适度改善复合材料的机械稳定性。使用乙氧基化双酚A二甲基丙烯酸酯或氨基甲酸酯二甲基丙烯酸酯作为基础单体并添加适量的亲水性甲基丙烯酸2-羟乙酯或其异构体-α-羟基甲基丙烯酸乙酯似乎是在保持高DVC的同时最大化填料的再矿化能力的有前途的途径。探索 ACP 填料和聚合物基质的结构/组成/性质关系很复杂，但对于更好地了解控制生物活性 ACP 填料溶解/再沉淀的基本机制以及最终了解复合材料用于临床评估的适用性至关重要。
Our studies of amorphous calcium phosphate (ACP)-based materials over the last decade have yielded bioactive polymeric composites capable of protecting teeth from demineralization or even regenerating lost tooth mineral. The anti-cariogenic/re-mineralizing potential of these ACP composites originates from their propensity, when exposed to the oral environment, to release in a sustained manner sufficient levels of mineral-forming calcium and phosphate ions to promote formation of stable apatitic tooth mineral. However, the less than optimal ACP filler/resin matrix cohesion, excessive polymerization shrinkage and water sorption of these experimental materials can adversely affect their physicochemical and mechanical properties, and, ultimately, limit their lifespan. This study demonstrates the effects of chemical structure and composition of the methacrylate monomers used to form the matrix phase of composites on degree of vinyl conversion (DVC) and water sorption of both copolymers and composites and the release of mineral ions from the composites. Modification of ACP surface via introducing cations and/or polymers ab initio during filler synthesis failed to yield mechanically improved composites. However, moderate improvement in composite’s mechanical stability without compromising its remineralization potential was achieved by silanization and/or milling of ACP filler. Using ethoxylated bisphenol A dimethacrylate or urethane dimethacrylate as base monomers and adding moderate amounts of hydrophilic 2-hydroxyethyl methacrylate or its isomer ethyl-α-hydroxymethacrylate appears to be a promising route to maximize the remineralizing ability of the filler while maintaining high DVC. Exploration of the structure/composition/property relationships of ACP fillers and polymer matrices is complex but essential for achieving a better understanding of the fundamental mechanisms that govern dissolution/re-precipitation of bioactive ACP fillers, and, ultimately, the suitability of the composites for clinical evaluation.
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影响因子：
1.7
作者：
Antonucci, JM;Skrtic, D
通讯作者：
Skrtic, D
影响因子：
2.3
作者：
Antonucci JM;O'Donnell JN;Schumacher GE;Skrtic D
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Skrtic D
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5
作者：
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作者：
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