Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach.
Early-life gut microbiota and its connection to metabolic health in children: Perspective on ecological drivers and need for quantitative approach.
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DOI：
10.1016/j.ebiom.2021.103475
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发表时间：
2021-07
期刊：
影响因子：
11.1
通讯作者：
Salonen A
中科院分区：
文献类型：
--
作者：
Jian C;Carpén N;Helve O;de Vos WM;Korpela K;Salonen A
肠道菌群的定植和发育通过其对宿主代谢和免疫稳态的强大影响而与儿科代谢紊乱有关。在这里，我们总结了早期肠道微生物群和儿科超重和肥胖的人类研究的证据。如果微生物群的组装模式及其健康后果可以解码，那么早期肠道微生物群的操纵可能代表了对抗儿科人群中迅速发展的代谢紊乱的有希望的目标。因此，在这篇综述中，我们特别关注影响早期肠道微生物群群落动态的重要生态驱动因素。然后，我们讨论了通常研究暴露的知识差距，将肠道微生物群与代谢紊乱联系起来，特别是关于母体因素和抗生素使用。这篇综述也试图为未来的研究指明方向，旨在确定基于肠道微生物群的儿科代谢紊乱的预测和纠正措施。肠道微生物群;新陈代谢;儿童超重和肥胖；生态驱动程序;动力学;婴儿
The colonisation and development of the gut microbiota has been implicated in paediatric metabolic disorders via its powerful effect on host metabolic and immune homeostasis. Here we summarise the evidence from human studies on the early gut microbiota and paediatric overweight and obesity. Manipulation of the early gut microbiota may represent a promising target for countering the burgeoning metabolic disorders in the paediatric population, provided the assembly patterns of microbiota and their health consequences can be decoded. Therefore, in this review, we pay particular attention to the important ecological drivers affecting the community dynamics of the early gut microbiota. We then discuss the knowledge gaps in commonly studied exposures linking the gut microbiota to metabolic disorders, especially regarding maternal factors and antibiotic use. This review also attempts to give directions for future studies aiming to identify predictive and corrective measures for paediatric metabolic disorders based on the gut microbiota. Gut microbiota; Metabolism; Paediatric overweight and obesity; Ecological driver; Dynamics; Infants
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