High-Efficiency Cell-Penetrating Helical Poly(phenyl isocyanide) Chains Modified Cellular Tracer and Nanovectors with Thiol Ratiometric Fluorescence Imaging Performance
High-Efficiency Cell-Penetrating Helical Poly(phenyl isocyanide) Chains Modified Cellular Tracer and Nanovectors with Thiol Ratiometric Fluorescence Imaging Performance
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具有硫醇比率荧光成像性能的高效细胞穿透螺旋聚（苯基异氰）链修饰的细胞示踪剂和纳米载体
DOI：
10.1021/acs.macromol.7b00669
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发表时间：
2017-05
期刊：
影响因子：
5.5
通讯作者：
Wue Zong Quan
中科院分区：
文献类型：
--
作者：
Han Xin;Zhang Jian;Qiao Chen Yang;Zhang Wen Ming;Yin Jun;Wue Zong Quan
为了精确跟踪内吞过程并确定药物载体在细胞中的内部位置，具有高灵敏度和多功能性的荧光示踪剂是最强大的工具之一。然而，传统的单荧光探针往往受到背景荧光的干扰或缺乏长时间的监测能力，导致分辨率和效率较低。为了克服这一缺点，能够抑制荧光和比率性质的纳米载体成为迫切需要的解决方案。在这篇贡献中，从五氟苯基酯（PFP）和四苯乙烯（TPE）官能化的苯基异腈（PI）单体以及1-亲水性（HP）PI单体开始，（PFPPI-共-TPEPI-共-HPPI）-b-HPPPI，通过与苯乙炔基Pd（II）的连续活性共聚合，复合物作为单一催化剂在一锅中。二硫...
In order to precisely tail the endocytosis process and determine the internal location of drug carriers in cells, fluorescent tracers with high sensitivity and versatility are one of the most powerful tools. Nevertheless, conventional single fluorescent probes always suffered from the interference of background fluorescence or the lack of long-time monitoring capability, resulting in the low resolution and efficiency. To overcome this drawback, nanocarriers capable of multicolor fluorogenic and ratiometric properties became an urgently needed solution. In this contribution, starting from pentafluorophenyl ester (PFP)- and tetraphenylethene (TPE)-functionalized phenyl isocyanide (PI) monomers as well as l-hydrophilic (HP) PI monomers, a type of well-defined amphiphilic block copolymer, P(PFPPI-co-TPEPI-co-HPPI)-b-HPPPI, with controlled molecular weights and tunable compositions was prepared through sequential living copolymerization with phenylethynyl Pd(II) complex as a single catalyst in one pot. Disulfi...
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影响因子：
15
作者：
Viger, Mathieu L.;Sankaranarayanan, Jagadis;Lux, Caroline de Gracia;Chan, Minnie;Almutairi, Adah
通讯作者：
Almutairi, Adah
影响因子：
6.7
作者：
Youyong Yuan;Yuanzeng Min;Q. Hu;B. Xing;B. Liu
通讯作者：
Youyong Yuan;Yuanzeng Min;Q. Hu;B. Xing;B. Liu
影响因子：
7.015
作者：
Zhang Z;Yin L;Tu C;Song Z;Zhang Y;Xu Y;Tong R;Zhou Q;Ren J;Cheng J
通讯作者：
Cheng J
影响因子：
29.4
作者：
Fan, Quli;Cheng, Kai;Yang, Zhen;Zhang, Ruiping;Yang, Min;Hu, Xiang;Ma, Xiaowei;Bu, Lihong;Lu, Xiaomei;Xiong, Xiaoxing;Huang, Wei;Zhao, Heng;Cheng, Zhen
通讯作者：
Cheng, Zhen
DOI：
10.1021/jp202112e
发表时间：
2011-05
期刊：
The journal of physical chemistry. B
影响因子：
--
作者：
Xiqi Zhang;Zhenguo Chi;Jianyong Zhang;Hai-yin Li;Bingjia Xu;Xiaofang Li;Siwei Liu;Yi Zhang
通讯作者：
Xiqi Zhang;Zhenguo Chi;Jianyong Zhang;Hai-yin Li;Bingjia Xu;Xiaofang Li;Siwei Liu;Yi Zhang