Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice.
Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice.
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DOI：
10.1002/adma.201402972
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发表时间：
2015-02-04
影响因子：
29.4
通讯作者：
Cheng, Zhen
中科院分区：
文献类型：
--
作者：
Fan, Quli;Cheng, Kai;Yang, Zhen;Zhang, Ruiping;Yang, Min;Hu, Xiang;Ma, Xiaowei;Bu, Lihong;Lu, Xiaomei;Xiong, Xiaoxing;Huang, Wei;Zhao, Heng;Cheng, Zhen
关键词：
光声成像（派）是一种新兴的生物医学成像技术，具有很强的光学吸收对比度和很高的超声分辨率，可以克服传统光学成像技术的深度和分辨率限制。[1]使用近红外（NIR，650-900 nm）吸收材料作为外源性造影剂已被广泛应用，因为它提高了派敏感性和深部组织穿透能力。随着纳米技术的快速发展，许多无机纳米材料，如金，[2]银，[3]铜[4]和磁性纳米颗粒[5]（NP），以及一些有机纳米材料，如碳纳米管[6]已被评估为派造影剂。这些材料中的许多还与感兴趣的靶向部分缀合，并在体外和体内表现出优异的派性质。然而，这些纳米材料的非生物降解性和潜在的长期毒性严重阻碍了它们的临床转化。最近，具有高NIR吸收特性的共轭聚合物NP [7]已被开发为有吸引力的派试剂。但其在生物体内的降解性和代谢性差，一直是临床应用的难题。相比之下，传统的近红外吸收和发射小分子有机染料，如吲哚菁绿色（ICG）[8]和其他近红外染料[9]已显示出对派有吸引力的特性。特别是，ICG已被食品和药物管理局批准用于患者使用，突出了
Photoacoustic imaging (PAI) is a newly emerging technique in biomedical imaging that provides strong optical absorption contrast and high ultrasonic resolution, which could overcome the depth and resolution limits of conventional optical imaging techniques.[1] Using near-infrared (NIR, 650–900 nm) absorptive materials as exogenous contrast agents has been widely applied because it improves PAI sensitivity and deep tissue penetration ability. With the rapid development of nanotechnology, numerous inorganic nanomaterials, such as gold,[2] silver,[3] copper [4], and magnetic nanoparticles [5](NPs), and a few organic nanomaterials such as carbon nanotubes [6] have been evaluated as PAI contrast agents. Many of these materials have also been conjugated with targeting moieties of interest and exhibited excellent PAI properties in vitro and in vivo. However, the nonbiodegradability and potential long-term toxicity of these nanomaterials severely hinder their clinical translation. More recently, conjugated polymer NPs with high NIR-absorption property [7] have been developed as attractive PAI agents. But their poor biodegradability and metabolism in living body remains a problem for clinical use. In comparison, traditional NIR-absorptive and emissive small molecular organic dyes, such as indocyanine green (ICG)[8] and other NIR dyes,[9] have shown attractive properties for PAI. Especially, ICG has been approved by the Food and Drug Administration for patient use, highlighting the
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用于活体小鼠高灵敏度和多重研究的增强型光声成像剂系列。
影响因子：
17.1
作者：
de la Zerda A;Bodapati S;Teed R;May SY;Tabakman SM;Liu Z;Khuri-Yakub BT;Chen X;Dai H;Gambhir SS
通讯作者：
Gambhir SS
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
19
作者：
Liu, Yu;Wang, Ke-Rang;Jiang, Bang-Ping
通讯作者：
Jiang, Bang-Ping
影响因子：
14
作者：
Lu, Wei;Huang, Qian;Ku, Geng;Wen, Xiaoxia;Zhou, Min;Guzatov, Dmitry;Brecht, Peter;Su, Richard;Oraevsky, Alexander;Wang, Lihong V.;Li, Chun
通讯作者：
Li, Chun