Meiotic Chromosome Dynamics in Zebrafish.

Meiotic Chromosome Dynamics in Zebrafish.
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DOI:
10.3389/fcell.2021.757445
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发表时间:
2021
影响因子:
5.5
通讯作者:
Burgess SM
Burgess SM
中科院分区:
生物学2区
文献类型:
--
作者:
Imai Y;Olaya I;Sakai N;Burgess SM

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Recent studies in zebrafish have revealed key features of meiotic chromosome dynamics, including clustering of telomeres in the bouquet configuration, biogenesis of chromosome axis structures, and the assembly and disassembly of the synaptonemal complex that aligns homologs end-to-end. The telomere bouquet stage is especially pronounced in zebrafish meiosis and sub-telomeric regions play key roles in mediating pairing and homologous recombination. In this review, we discuss the temporal progression of these events in meiosis prophase I and highlight the roles of proteins associated with meiotic chromosome architecture in homologous recombination. Finally, we discuss the interplay between meiotic mutants and gonadal sex differentiation and future research directions to study meiosis in living cells, including cell culture.
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