Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.
Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease.
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DOI：
10.3109/07853890.2011.645498
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发表时间：
2013-02
影响因子：
4.4
通讯作者：
Loo Bv
中科院分区：
文献类型：
--
作者：
Bachschmid MM;Schildknecht S;Matsui R;Zee R;Haeussler D;Cohen RA;Pimental D;Loo Bv
特征性形态学和分子学改变，如血管壁增厚和一氧化氮减少，发生在衰老的血管系统中，导致血管稳态的逐渐丧失。因此，患急性和慢性心血管疾病的风险随着年龄的增长而增加。目前对内皮功能的潜在分子机制的研究表明，活性氧和氮物质在促进血管稳态或过量形成时导致有害作用方面具有双重性。此外，血管平滑肌细胞的功能和氧化还原状态的变化有助于年龄相关的血管重塑。自由基形成的年龄依赖性增加导致一氧化氮信号级联的恶化，改变和激活前列腺素代谢，并促进新的氧化翻译后蛋白质修饰，干扰血管和细胞信号通路。结果，出现血管功能障碍。补偿机制最初被激活以科普年龄诱导的氧化应激，但变得无效，这导致生物大分子的不可逆氧化修饰。这些发现支持了“衰老的自由基理论”，但也表明活性氧和氮是调节血管稳态的重要信号分子。
Characteristic morphological and molecular alterations such as vessel wall thickening and reduction of nitric oxide occur in the aging vasculature leading to the gradual loss of vascular homeostasis. Consequently, the risk of developing acute and chronic cardiovascular diseases increases with age. Current research of the underlying molecular mechanisms of endothelial function demonstrates a duality of reactive oxygen and nitrogen species in contributing to vascular homeostasis or leading to detrimental effects when formed in excess. Furthermore, changes in function and redox status of vascular smooth muscle cells contribute to age-related vascular remodeling. The age-dependent increase in free radical formation causes deterioration of the nitric oxide signaling cascade, alters and activates prostaglandin metabolism, and promotes novel oxidative posttranslational protein modifications that interfere with vascular and cell signaling pathways. As a result, vascular dysfunction manifests. Compensatory mechanisms are initially activated to cope with age-induced oxidative stress, but become futile, which results in irreversible oxidative modifications of biological macromolecules. These findings support the ‘free radical theory of aging’ but also show that reactive oxygen and nitrogen species are essential signaling molecules, regulating vascular homeostasis.
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影响因子：
4.3
作者：
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通讯作者：
Shadel, Gerald S.
影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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DOI：
10.1161/atvbaha.107.146852
发表时间：
2007-09-01
影响因子：
8.7
作者：
Brown, Kathryn A.;Didion, Sean P.;Faraci, Frank M.
通讯作者：
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影响因子：
8.3
作者：
BURKE, GL;EVANS, GW;HEISS, G
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