Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.
Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats.
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DOI：
10.1016/j.ejphar.2008.10.016
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发表时间：
2008-12-14
影响因子：
5
通讯作者：
Rose JE
中科院分区：
文献类型：
--
作者：
Levin ED;Slade S;Johnson M;Petro A;Horton K;Williams P;Rezvani AH;Rose JE
Nicotine intake constitutes a principal mechanism for tobacco addiction. In addition to primary effects on nicotinic acetylcholine receptors, nicotine has cascading effects, which may underlie its neurobehavioral actions. Nicotine induces serotonin (5-HT) release, which has not classically been thought to be involved in tobacco addiction. However, addiction can be characterized more as a disorder of compulsion than a disorder of enjoyment. 5-HT mechanisms play key roles in compulsive disorders. Nicotine-induced 5-HT release may be a key to tobacco addiction. Ketanserin, a 5-HT2a and 2c receptor antagonist, significantly attenuates nicotine effects on attention and memory. These studies were conducted to determine if ketanserin would reduce nicotine self-administration in rats. Male Sprague- Dawley rats (N=12) were given initial food pellet training and then 10 sessions of nicotine self-administration training (0.03 mg/kg/infusion, i.v.). Then the rats were administered ketanserin (1 or 2 mg/kg, s.c.) or the saline vehicle. Ketanserin (2 mg/kg) significantly decreased nicotine self-administration. This did not seem to be due to sedative or amnestic effects of ketanserin. In a second study, the effects of repeated administration of 2 mg/kg ketanserin (N=11) vs. saline injections (N=10) were examined. In the initial phase, the acute effectiveness of ketanserin in significantly reducing nicotine self-administration was replicated. The effect became attenuated during the following several sessions, but the significant effect became re-established during the final phases of this two-week study. 5-HT mechanisms play critical roles in the maintenance of nicotine self-administration. Better understanding of those roles may help lead to new 5-HT-based treatments for tobacco addiction.
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影响因子：
3.8
作者：
DAMAJ, MI;GLENNON, RA;MARTIN, BR
通讯作者：
MARTIN, BR
影响因子：
3.4
作者：
Quarta, Davide;Naylor, Christopher G.;Stolerman, Ian P.
通讯作者：
Stolerman, Ian P.
影响因子：
3.4
作者：
Rezvani, AH;Caldwell, DP;Levin, ED
通讯作者：
Levin, ED
DOI：
10.1111/j.1440-1614.2006.01841.x
发表时间：
2006-06-01
影响因子：
4.6
作者：
Barnes, Mark;Lawford, Bruce R.;Young, Ross McD.
通讯作者：
Young, Ross McD.
DOI：
10.1111/j.1749-6632.1999.tb09282.x
发表时间：
1999-01-01
期刊：
ADVANCING FROM THE VENTRAL STRIATUM TO THE EXTENDED AMYGDALA
影响因子：
--
作者：
Koob, GF
通讯作者：
Koob, GF