A computerized technique to assess language use patterns in patients with frontotemporal dementia.
A computerized technique to assess language use patterns in patients with frontotemporal dementia.
复制标题
一种计算机化技术，用于评估额颞痴呆患者的语言使用模式。
DOI：
10.1016/j.jneuroling.2009.12.001
复制
发表时间：
2010-03-01
影响因子：
2
通讯作者：
Knopman, David S.
中科院分区：
文献类型：
--
作者：
Pakhomov, Serguei V. S.;Smith, Glenn E.;Marino, Susan;Birnbaum, Angela;Graff-Radford, Neill;Caselli, Richard;Boeve, Bradley;Knopman, David S.
关键词：
额颞叶变性（FTLD）是一种影响语言的神经退行性疾病。我们应用计算机信息理论技术来评估语言相关FTLD症状的类型和严重程度。来自三个参与医疗中心的48名FTLD患者的音频记录样本使用Cookie盗窃图片刺激进行了诱导。音频转录和分析计算两个措施：困惑指数和词汇（OOV）率。困惑指数表示FTLD患者使用的单词模式与健康成人模式相比的偏差程度。OOV率表示FTLD患者使用的词的比例，而健康说话者没有使用这些词来描述刺激。在这个临床特征良好的队列中，困惑指数和OOV率对语义性痴呆的自发性语言表现以及语义性痴呆和FTLD的进行性逻辑缺失性失语变体之间的区别敏感。我们的研究不仅支持了一种新的技术，用于在临床试验环境中表征FTLD的语言相关症状，还验证了语义痴呆作为一种独特综合征的临床诊断基础。
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder that affects language. We applied a computerized information-theoretic technique to assess the type and severity of language-related FTLD symptoms. Audio-recorded samples of 48 FTLD patients from three participating medical centers were elicited using the Cookie Theft picture stimulus. The audio was transcribed and analyzed by calculating two measures: a perplexity index and an out-of-vocabulary (OOV) rate. The perplexity index represents the degree of deviation in word patterns used by FTLD patients compared to patterns of healthy adults. The OOV rate represents the proportion of words used by FTLD patients that were not used by the healthy speakers to describe the stimulus. In this clinically well-characterized cohort, the perplexity index and the OOV rate were sensitive to spontaneous language manifestations of semantic dementia and the distinction between semantic dementia and progressive logopenic aphasia variants of FTLD. Our study not only supports a novel technique for the characterization of language-related symptoms of FTLD in clinical trial settings, it also validates the basis for the clinical diagnosis of semantic dementia as a distinct syndrome.
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影响因子：
2
作者：
Gordon, Jean K.
通讯作者：
Gordon, Jean K.
影响因子：
2
作者：
Ash, Sharon;Moore, Peachie;Vesely, Luisa;Gunawardena, Delani;McMillan, Corey;Anderson, Chivon;Avants, Brian;Grossman, Murray
通讯作者：
Grossman, Murray
影响因子：
9.9
作者：
Ash, S;Moore, P;Grossman, M
通讯作者：
Grossman, M
影响因子：
9.9
作者：
Josephs, K. A.;Whitwell, J. L.;Petersen, R. C.
通讯作者：
Petersen, R. C.
DOI：
10.1044/jshr.3702.399
发表时间：
1994-04-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
BROOKSHIRE, RH;NICHOLAS, LE
通讯作者：
NICHOLAS, LE