Non-Fluent Speech in Frontotemporal Lobar Degeneration.
Non-Fluent Speech in Frontotemporal Lobar Degeneration.
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DOI：
10.1016/j.jneuroling.2008.12.001
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
--
作者：
Ash, Sharon;Moore, Peachie;Vesely, Luisa;Gunawardena, Delani;McMillan, Corey;Anderson, Chivon;Avants, Brian;Grossman, Murray
我们研究了言语流畅性受损的认知和神经基础，这是原发性进行性失语的一个中心特征。对35例额颞叶变性（FTLD）患者的言语流畅性进行了评估，这些患者表现为进行性非流畅性失语（PNFA，n=11）、语义性痴呆（SemD，n=12）或无失语的社交和执行障碍（SOC/EXEC，n=12）。流畅性被量化为在一个扩展的，半结构化的语音样本中每分钟的字数。这与语音样本的语言特征和神经心理学措施有关。PNFA患者的流畅性明显低于对照组和其他FTLD患者。流畅性与语法表达相关，但与言语错误或执行困难无关。SemD和SOC/EXEC患者的流畅性也低于对照组。在SemD中，流畅性与语义有限的内容相关。在SOC/EXEC中，流利性与执行限制相关。对整个FTLD患者队列进行基于体素的高分辨率MRI相关流畅性与左下额叶、颞叶和上级颞区灰质体积的形态测定分析。该区域在每个FTLD亚组中部分重叠不同的萎缩区。因此，它似乎在言语流畅性中起着至关重要的作用，在不同的FTLD亚组中，言语流畅性可以以不同的方式被打断。
We investigated the cognitive and neural bases of impaired speech fluency, a central feature of primary progressive aphasia. Speech fluency was assessed in 35 patients with frontotemporal lobar degeneration (FTLD) who presented with progressive non-fluent aphasia (PNFA, n=11), semantic dementia (SemD, n=12), or a social and executive disorder without aphasia (SOC/EXEC, n=12). Fluency was quantified as the number of words per minute in an extended, semi-structured speech sample. This was related to language characteristics of the speech sample and to neuropsychological measures. PNFA patients were significantly less fluent than controls and other FTLD patients. Fluency correlated with grammatical expression but not with speech errors or executive difficulty. SemD and SOC/EXEC patients were also less fluent than controls. In SemD, fluency was associated with semantically limited content. In SOC/EXEC, fluency was associated with executive limitations. Voxel-based morphometry analyses of high-resolution MRI related fluency to gray matter volume in left inferior frontal, insula, and superior temporal regions for the entire cohort of FTLD patients. This region overlapped partially distinct atrophic areas in each FTLD subgroup. It thus appears to play a crucial role in speech fluency, which can be interrupted in different ways in different FTLD subgroups.
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影响因子：
4.8
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通讯作者：
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