Cell-cell interactions in rheumatoid arthritis synovium.
Cell-cell interactions in rheumatoid arthritis synovium.
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DOI：
10.1016/j.rdc.2010.02.004
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发表时间：
2010-05
影响因子：
2.3
通讯作者：
Lundy, Steven K.
中科院分区：
文献类型：
--
作者：
Fox, David A.;Gizinski, Alison;Morgan, Rachel;Lundy, Steven K.
关键词：
Understanding the pathogenesis of joint inflammation and destruction in rheumatoid arthritis involves dissection of the cellular and molecular interactions that occur in synovial tissue. Development of effective targeted therapies has been based on progress in achieving such insights. Safer and more specific approaches to treatment could flow from discovery of cell-cell interaction pathways that are relatively specific for inflammation of the joint, and less important in defense against systemic infection. This chapter highlights selected cell-cell interactions in rheumatoid arthritis synovium that may be worthy of evaluation as future therapeutic targets.
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