Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.

Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury.
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胎儿运动减少:胎盘脑损伤感染胎盘SARS-COV-2的迹象。

DOI:
10.3390/v13122517
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发表时间:
2021-12-15
期刊:
Viruses
影响因子:
--
通讯作者:
Giannoni E
Giannoni E
中科院分区:
其他
文献类型:
--
作者:
Favre G;Mazzetti S;Gengler C;Bertelli C;Schneider J;Laubscher B;Capoccia R;Pakniyat F;Ben Jazia I;Eggel-Hort B;de Leval L;Pomar L;Greub G;Baud D;Giannoni E

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新生儿COVID-19很罕见,主要是产后传播。然而,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)可感染胎盘并损害其功能。我们介绍了两例轻度母体COVID-19后5天胎动减少和胎儿心律异常的病例,需要在妊娠29 + 3周和32 + 1周进行紧急剖腹产,并导致脑损伤。胎盘检查显示广泛和多灶性慢性绒毛间炎,SARS-CoV-2刺突抗体和RT-qPCR检测的SARS-CoV-2呈强细胞质阳性。在一个病例中证实了垂直传播,两个新生儿都出现了广泛的囊性脑室周围白质软化。
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
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