Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets.
Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets.
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乙酰化和甲基化相关的表观遗传蛋白在其靶标的背景下。
DOI：
10.3390/genes8080196
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发表时间：
2017-08-07
期刊：
影响因子：
3.5
通讯作者：
Choi S
中科院分区：
文献类型：
--
作者：
Javaid N;Choi S
核小体表面覆盖着多种修饰，这些修饰由八种不同类型的酶永久保存。这些酶修饰DNA和组蛋白上的特定靶点，这些修饰已被很好地识别并称为“表观遗传学”。这些修饰通过影响非组蛋白向染色质募集或干扰染色质接触发挥关键作用。它们的存在决定了DNA的浓缩包装，并可以协调各种酶复合物的有序募集以进行DNA操作。这种基因修饰机制包括各种书写器、读取器和擦除器，它们具有独特的结构、功能和作用方式。对于人类疾病，研究主要集中在遗传机制上；然而，表观遗传网络平衡的改变可导致主要病理，包括智力迟钝、染色体不稳定综合征和各种类型的癌症。由于其关键的影响，巨大的潜力在于发展表观遗传治疗。在这方面，本文综述了主要表观遗传家族与其靶点的机制和结构相互作用，这将有助于找到更有效和安全的药物来治疗几种疾病。
The nucleosome surface is covered with multiple modifications that are perpetuated by eight different classes of enzymes. These enzymes modify specific target sites both on DNA and histone proteins, and these modifications have been well identified and termed “epigenetics”. These modifications play critical roles, either by affecting non-histone protein recruitment to chromatin or by disturbing chromatin contacts. Their presence dictates the condensed packaging of DNA and can coordinate the orderly recruitment of various enzyme complexes for DNA manipulation. This genetic modification machinery involves various writers, readers, and erasers that have unique structures, functions, and modes of action. Regarding human disease, studies have mainly focused on the genetic mechanisms; however, alteration in the balance of epigenetic networks can result in major pathologies including mental retardation, chromosome instability syndromes, and various types of cancers. Owing to its critical influence, great potential lies in developing epigenetic therapies. In this regard, this review has highlighted mechanistic and structural interactions of the main epigenetic families with their targets, which will help to identify more efficient and safe drugs against several diseases.
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影响因子：
64.5
作者：
Ballas, N;Grunseich, C;Mandel, G
通讯作者：
Mandel, G
影响因子：
11.5
作者：
Banerji, Udai;van Doorn, Leni;Eskens, Ferry A. L. M.
通讯作者：
Eskens, Ferry A. L. M.
DOI：
10.1074/jbc.m111.223453
发表时间：
2011-05-20
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Alvarez F;Muñoz F;Schilcher P;Imhof A;Almouzni G;Loyola A
通讯作者：
Loyola A
影响因子：
14.9
作者：
Angrisano, T;Lembo, F;Pero, R;Natale, F;Fusco, A;Avvedimento, VE;Bruni, CB;Chiariotti, L
通讯作者：
Chiariotti, L
影响因子：
30.8
作者：
Borrow, J;Stanton, VP;Housman, DE
通讯作者：
Housman, DE