Diagnosis of Leptomeningeal Metastasis in Women With Breast Cancer Through Identification of Tumor Cells in Cerebrospinal Fluid Using the CNSide™ Assay.

Diagnosis of Leptomeningeal Metastasis in Women With Breast Cancer Through Identification of Tumor Cells in Cerebrospinal Fluid Using the CNSide™ Assay.
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使用CNSIDE™测定法鉴定脑脊液中的肿瘤细胞,诊断乳腺癌女性的脑膜转移。

DOI:
10.1016/j.clbc.2021.11.002
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发表时间:
2022-06
影响因子:
3.1
通讯作者:
Kalinsky, Kevin
Kalinsky, Kevin
中科院分区:
医学3区
文献类型:
--
作者:
Wooster, Margaux;McGuinness, Julia E.;Fenn, Kathleen M.;Singh, Veena M.;Franks, Lauren E.;Lee, Shing;Cieremans, David;Lassman, Andrew B.;Hershman, Dawn L.;Crew, Katherine D.;Accordino, Melissa K.;Trivedi, Meghna S.;Iwamoto, Fabio;Welch, Mary R.;Haggiagi, Aya;Schultz, Robbie D.;Huynh, Lan;Sales, Edgar;Fisher, Deanna;Mayer, Julie Ann;Kreisl, Teri;Kalinsky, Kevin

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软脑膜转移是转移性乳腺癌的严重并发症,但脑脊液细胞病理学的低敏感性限制了其诊断。这项研究评估了一种新的检测方法,CNSide™,并证明了对LM的100%敏感性,以及受体评估和突变鉴定的能力。CNSide™可能是一种可行的检测LM的平台,可能作为一种诊断工具使用。
Leptomeningeal metastasis (LM) is a devastating complication of metastatic breast cancer; however, diagnosis is limited by low sensitivity of cerebrospinal fluid cytopathology. This study evaluates a novel assay, CNSide™, and demonstrates 100% sensitivity for LM and additionally, capacity for receptor assessment and mutation identification. CNSide™ may be a viable platform to detect LM, with potential use as a diagnostic tool.
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