Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques.
Methylation of OXT and OXTR genes, central oxytocin, and social behavior in female macaques.
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DOI：
10.1016/j.yhbeh.2020.104856
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发表时间：
2020-11
影响因子：
3.5
通讯作者：
Sanchez MM
中科院分区：
文献类型：
--
作者：
De Leon D;Nishitani S;Walum H;McCormack KM;Wilson ME;Smith AK;Young LJ;Sanchez MM
催产素（OXT）及其受体（OXTR）分别由OXT和OXTR编码。这些基因的可变甲基化与社交能力和神经内表型的变异性有关。在这里，我们研究了在群居的雌性恒河猴中，血液中OXTR或OXT甲基化是否能预测脑脊液（CSF）中OXT的浓度（n=166）和社会行为（n=207）。我们报告了人类和恒河猴OXT和OXTR的CpG位点之间的相似性，以及两个OXTR CpG单元甲基化与攻击行为之间的假定负相关（均P=0.003），尽管这一发现无法通过最严格的多重比较测试校正。我们也没有发现任何CpG位点甲基化与CSF OXT浓度之间有统计学意义的关联。因为所有测试的关联都没有经过统计校正，如果血液来源的这些基因甲基化与这里测量的行为和生理结果之间存在任何关系，那么效应量太小，无法用这个样本量可靠地检测到。这些结果不支持血液中OXT或OXTR甲基化与恒河猴CSF OXT浓度或社会行为密切相关的假设。然而，大脑或脸颊上皮中这些位点的甲基化可能与中枢OXT的释放和行为有关。最后，我们考虑了本探索性研究在统计能力背景下的局限性。
Oxytocin (OXT) and its receptor (OXTR) are encoded by OXT and OXTR, respectively. Variable methylation of these genes has been linked to variability in sociability and neuroendophenotypes. Here we examine whether OXTR or OXT methylation in blood predicts concentrations of OXT in cerebrospinal fluid (CSF) (n=166) and social behavior (n=207) in socially-housed female rhesus macaques. We report a similarity between human and rhesus CpG sites for OXT and OXTR and a putative negative association between methylation of two OXTR CpG units with aggressive behavior (both P=0.003), though this finding does not survive the most stringent correction for multiple comparison testing. We did not detect a statistically significant association between methylation of any CpG sites and CSF OXT concentrations, either. Because none of the tested associations survived statistical corrections, if there is any relationship between blood-derived methylation of these genes and the behavioral and physiological outcomes measured here, the effect size is too small to be detected reliably with this sample size. These results do not support the hypothesis that blood methylation of OXT or OXTR is robustly associated with CSF OXT concentration or social behavior in rhesus. It is possible, though, that methylation of these loci in the brain or in cheek epithelia may be associated with central OXT release and behavior. Finally, we consider the limitations of this exploratory study in the context of statistical power.
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影响因子：
3.2
作者：
Freeman SM;Young LJ
通讯作者：
Young LJ
人类血液和大脑衰老的一致性和不一致的DNA甲基化特征。
影响因子：
3.9
作者：
Farré P;Jones MJ;Meaney MJ;Emberly E;Turecki G;Kobor MS
通讯作者：
Kobor MS
DOI：
10.1016/j.ijpsycho.2018.01.008
发表时间：
2019-03
期刊：
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
影响因子：
--
作者：
Ebner NC;Lin T;Muradoglu M;Weir DH;Plasencia GM;Lillard TS;Pournajafi-Nazarloo H;Cohen RA;Sue Carter C;Connelly JJ
通讯作者：
Connelly JJ
影响因子：
14.9
作者：
Coolen, Marcel W;Statham, Aaron L;Gardiner-Garden, Margaret;Clark, Susan J
通讯作者：
Clark, Susan J
影响因子：
7.6
作者：
Andari, Elissar;Nishitani, Shota;Young, Larry J.
通讯作者：
Young, Larry J.