Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole.
Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole.
复制标题
奥美拉唑治疗期间幽门螺杆菌状态对胃内 pH 值的影响。
作者：
Elena F. Verdú;D. Armstrong;R. Fraser;F. Viani;J. Idström;C. Cederberg;A. Blum
为了检验幽门螺杆菌感染的假设与奥美拉唑治疗期间胃内酸度降低有关，在18 h幽门螺杆菌阳性和14 H幽门螺杆菌阴性受试者中进行了卧床24小时双点胃pH记录。每天20毫克安慰剂或奥美拉唑课程后，每个主题的两个pH录音之间的两个pH录音之间有四到六周的冲洗期。在安慰剂期间，中位24小时pH值在语料库中没有差异（H幽门螺杆菌阳性= 1.5，负= 1.4； p = 0.9）或Antrum（H幽门螺杆菌阳性= 1.3，负= 1.2; p = 0.1）。然而，在奥美拉唑治疗期间，幽门螺杆菌阳性受试者的中值24小时pH值较高（幽门螺杆菌阳性= 5.5，阴性= 4.0; p = 0.001）和antrum（H幽门螺杆菌阳性= 5.5，阴性= 3.5， ; p = 0.0004）。在安慰剂治疗过程中，两组之间的唯一区别是幽门螺杆菌阳性组的急性较高的夜间pH值。在奥美拉唑治疗期间，胃pH值在幽门螺杆菌阳性组的胃pH值均更高，除幽门螺杆菌阳性基团外，除了库库中的进餐时间。这些数据表明，与幽门螺杆菌的幽门螺杆菌感染相比，奥美拉唑在患有H幽门螺杆菌感染的受试者中产生的胃酸性降低更大。但是，尚不知道幽门螺杆菌感染与奥美拉唑疗效增加之间是否存在因果关系。
To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the two pH recordings made in each subject after one week courses of placebo or omeprazole, 20 mg daily. During placebo, median 24 hour pH values were not different in the corpus (H pylori positive = 1.5, negative = 1.4; p = 0.9) or antrum (H pylori positive = 1.3, negative = 1.2; p = 0.1). However, during omeprazole treatment, median 24 hour pH values were higher in H pylori positive subjects, both in the corpus (H pylori positive = 5.5, negative = 4.0; p = 0.001) and antrum (H pylori positive = 5.5, negative = 3.5; p = 0.0004). During placebo treatment, the only difference between the two groups was a higher later nocturnal pH in the antrum in the H pylori positive group. During omeprazole treatment, gastric pH was higher both in the corpus and in the antrum in the H pylori positive group for all periods, except for mealtime in the corpus. These data indicate that omeprazole produces a greater decrease in gastric acidity in subjects with H pylori infection than in those who are H pylori negative. It is not, however, known whether there is a causal relationship between H pylori infection and increased omeprazole efficacy.
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影响因子：
3.1
作者：
Madeline Vargas;A. Lee;James G. Fox;David R. Cave
通讯作者：
Madeline Vargas;A. Lee;James G. Fox;David R. Cave
DOI：
10.1172/jci113893
发表时间：
1989-02
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
P. Karnik;S. J. Monahan;M. Wolfe
通讯作者：
P. Karnik;S. J. Monahan;M. Wolfe
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DOI：
10.1152/ajpgi.1993.265.4.g752
发表时间：
1993
期刊：
The American journal of physiology
影响因子：
--
作者：
Tari,A;Yamamoto,G;Sumii,K;Sumii,M;Takehara,Y;Haruma,K;Kajiyama,G;Wu,V;Sachs,G;Walsh,JH
通讯作者：
Walsh,JH
13CO2 测量的临床应用。
DOI：
--
发表时间：
1982
期刊：
Federation proceedings
影响因子：
--
作者：
Klein,PD
通讯作者：
Klein,PD