Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration.
Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration.
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长链非编码RNA在黄斑变性中的作用
DOI：
10.3390/ijms22179178
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发表时间：
2021-08-25
影响因子：
5.6
通讯作者：
Kaarniranta K
中科院分区：
文献类型：
--
作者：
Blasiak J;Hyttinen JMT;Szczepanska J;Pawlowska E;Kaarniranta K
年龄相关性黄斑变性（AMD）是老年人群视力损害的主要原因，但其发病机制尚不清楚且缺乏有效的治疗方法。年龄和家族史是最重要的 AMD 危险因素，并且已确定了几个与 AMD 相关的位点。最近，表观遗传谱也与 AMD 相关，并且一些长非编码 RNA (lncRNA) 被证明参与 AMD 发病机制。 Vax2os1/2（腹侧前同源盒 2 相反链亚型 1）lncRNA 可能调节眼部促血管生成因子和抗血管生成因子之间的平衡，从而导致湿性 AMD。 ZNF503-AS1（锌指蛋白 503 反义 RNA 2）和 LINC00167 lncRNA 可以抑制应激诱导的视网膜色素上皮细胞去分化。 PWRN2（Prader-Willi 区非蛋白编码 RNA 2）lncRNA 的过度表达会加剧氧化应激引起的 RPE 细胞凋亡和线粒体损伤。据报道，其他几种 lncRNA 对 AMD 具有保护或有害作用。然而，许多研究仅限于生物信息学患者或模型系统中 lncRNA 与 AMD 之间的关联。因此，对 AMD 中 lncRNA 的进一步研究是合理的，并且应该通过机制和临床研究来丰富它们，以验证高通量体外研究中获得的结论。
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with poorly known pathogenesis and lack of effective treatment. Age and family history are the strongest AMD risk factors, and several loci were identified to contribute to AMD. Recently, also the epigenetic profile was associated with AMD, and some long non-coding RNAs (lncRNAs) were shown to involve in AMD pathogenesis. The Vax2os1/2 (ventral anterior homeobox 2 opposite strand isoform 1) lncRNAs may modulate the balance between pro- and anti-angiogenic factors in the eye contributing to wet AMD. The stress-induced dedifferentiation of retinal pigment epithelium cells can be inhibited by the ZNF503-AS1 (zinc finger protein 503 antisense RNA 2) and LINC00167 lncRNAs. Overexpression of the PWRN2 (Prader-Willi region non-protein-coding RNA 2) lncRNA aggravated RPE cells apoptosis and mitochondrial impairment induced by oxidative stress. Several other lncRNAs were reported to exert protective or detrimental effects in AMD. However, many studies are limited to an association between lncRNA and AMD in patients or model systems with bioinformatics. Therefore, further works on lncRNAs in AMD are rational, and they should be enriched with mechanistic and clinical studies to validate conclusions obtained in high-throughput in vitro research.
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影响因子：
13.7
作者：
Colijn JM;Buitendijk GHS;Prokofyeva E;Alves D;Cachulo ML;Khawaja AP;Cougnard-Gregoire A;Merle BMJ;Korb C;Erke MG;Bron A;Anastasopoulos E;Meester-Smoor MA;Segato T;Piermarocchi S;de Jong PTVM;Vingerling JR;Topouzis F;Creuzot-Garcher C;Bertelsen G;Pfeiffer N;Fletcher AE;Foster PJ;Silva R;Korobelnik JF;Delcourt C;Klaver CCW;EYE-RISK consortium;European Eye Epidemiology (E3) consortium
通讯作者：
European Eye Epidemiology (E3) consortium
影响因子：
3.5
作者：
Alfano, G;Vitiello, C;Banfi, S
通讯作者：
Banfi, S
影响因子：
1.2
作者：
Dewell, Tessa E.;Gjoni, Ketrin;Conklin, Bruce R.
通讯作者：
Conklin, Bruce R.
影响因子：
4.5
作者：
Andergassen, Daniel;Muckenhuber, Markus;Hudson, Quanah J.
通讯作者：
Hudson, Quanah J.
影响因子：
5.3
作者：
Blasiak, Janusz;Watala, Cezary;Kaarniranta, Kai
通讯作者：
Kaarniranta, Kai