Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future.
Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future.
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DOI：
10.1016/j.ophtha.2017.05.035
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发表时间：
2017-12
期刊：
影响因子：
13.7
通讯作者：
European Eye Epidemiology (E3) consortium
中科院分区：
文献类型：
--
作者：
Colijn JM;Buitendijk GHS;Prokofyeva E;Alves D;Cachulo ML;Khawaja AP;Cougnard-Gregoire A;Merle BMJ;Korb C;Erke MG;Bron A;Anastasopoulos E;Meester-Smoor MA;Segato T;Piermarocchi S;de Jong PTVM;Vingerling JR;Topouzis F;Creuzot-Garcher C;Bertelsen G;Pfeiffer N;Fletcher AE;Foster PJ;Silva R;Korobelnik JF;Delcourt C;Klaver CCW;EYE-RISK consortium;European Eye Epidemiology (E3) consortium
视网膜相关性黄斑变性（AMD）是欧洲血统老年人常见的复杂疾病。多年来，风险状况和治疗选择发生了很大变化，这可能影响了疾病的流行和结果。我们使用欧洲眼科流行病学（E3）联盟确定了1990年至2013年欧洲早期和晚期AMD的患病率，并对未来进行了预测。流行率数据的荟萃分析。来自欧洲10个国家的14个基于人群的队列中共有42080名40岁及以上的个体参与。根据眼底照片使用鹿特丹分类法诊断AMD。早期和晚期AMD的患病率是使用随机效应荟萃分析计算的，该分析按年龄、出生队列、性别、地理区域和研究时间段分层。比较了晚期AMD亚型、地图状萎缩（GA）和脉络膜新生血管（CNV）之间的最佳矫正视力（BCVA）。早期和晚期AMD的患病率、BCVA和AMD病例数。早期AMD的患病率从3.5%（95%置信区间[CI] 2.1%-5.0%），年龄55-59岁的患者为17.6%（95% CI 13.6%-21.5%）;对于晚期AMD，这些数字分别为0.1%（95% CI 0.04%-0.3%）和9.8%（95% CI 6.3%-13.3%）。我们观察到2006年后晚期AMD的患病率下降，在70岁后变得最突出。除最老年龄组中的晚期AMD外，所有年龄组的患病率在性别上相似，并且发现了显示北方欧洲CNV患病率较高的趋势。2006年以后，视力受损的CNV患者的眼睛和年龄≥80岁的受试者更少（P = 0.016）。AMD的预测显示，尽管患病率下降，但受影响的人数几乎增加了一倍。到2040年，欧洲早期AMD患者的数量将在1490万至2150万之间，晚期AMD患者将在390万至480万之间。我们观察到在过去的20年里，在欧洲，AMD的患病率下降，CNV的视力改善。更健康的生活方式和抗血管内皮生长因子治疗的实施是最可能的解释。然而，受影响的受试者人数将在未来20年内大幅增加。AMD仍然是欧洲人的一个重大公共卫生问题。
Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly of European ancestry. Risk profiles and treatment options have changed considerably over the years, which may have affected disease prevalence and outcome. We determined the prevalence of early and late AMD in Europe from 1990 to 2013 using the European Eye Epidemiology (E3) consortium, and made projections for the future. Meta-analysis of prevalence data. A total of 42 080 individuals 40 years of age and older participating in 14 population-based cohorts from 10 countries in Europe. AMD was diagnosed based on fundus photographs using the Rotterdam Classification. Prevalence of early and late AMD was calculated using random-effects meta-analysis stratified for age, birth cohort, gender, geographic region, and time period of the study. Best-corrected visual acuity (BCVA) was compared between late AMD subtypes; geographic atrophy (GA) and choroidal neovascularization (CNV). Prevalence of early and late AMD, BCVA, and number of AMD cases. Prevalence of early AMD increased from 3.5% (95% confidence interval [CI] 2.1%–5.0%) in those aged 55–59 years to 17.6% (95% CI 13.6%–21.5%) in those aged ≥85 years; for late AMD these figures were 0.1% (95% CI 0.04%–0.3%) and 9.8% (95% CI 6.3%–13.3%), respectively. We observed a decreasing prevalence of late AMD after 2006, which became most prominent after age 70. Prevalences were similar for gender across all age groups except for late AMD in the oldest age category, and a trend was found showing a higher prevalence of CNV in Northern Europe. After 2006, fewer eyes and fewer ≥80-year-old subjects with CNV were visually impaired (P = 0.016). Projections of AMD showed an almost doubling of affected persons despite a decreasing prevalence. By 2040, the number of individuals in Europe with early AMD will range between 14.9 and 21.5 million, and for late AMD between 3.9 and 4.8 million. We observed a decreasing prevalence of AMD and an improvement in visual acuity in CNV occuring over the past 2 decades in Europe. Healthier lifestyles and implementation of anti–vascular endothelial growth factor treatment are the most likely explanations. Nevertheless, the numbers of affected subjects will increase considerably in the next 2 decades. AMD continues to remain a significant public health problem among Europeans.
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影响因子：
3.6
作者：
Jungjohann, SM;Lührmann, PM;Neuhäuser-Berthold, M
通讯作者：
Neuhäuser-Berthold, M
影响因子：
3.5
作者：
Crimmins, Eileen M.;Hayward, Mark D.;Brouard, Nicolas
通讯作者：
Brouard, Nicolas
影响因子：
39.3
作者：
Davies, Alisha Ruth;Smeeth, Liam;Grundy, Emily Marjatta Dorothea
通讯作者：
Grundy, Emily Marjatta Dorothea
影响因子：
13.7
作者：
Boyer, David S.;Heier, Jeffrey S.;Rubio, Roman G.
通讯作者：
Rubio, Roman G.
影响因子：
158.5
作者：
Gragoudas, ES;Adamis, AP;Guyer, DR
通讯作者：
Guyer, DR