Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease.
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患有正常认知和早期阿尔茨海默氏病的老年人的内嗅皮质TAU沉积和海马突触密度的关联。
DOI：
10.1016/j.neurobiolaging.2021.11.004
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发表时间：
2022-03
影响因子：
4.2
通讯作者：
van Dyck CH
中科院分区：
文献类型：
--
作者：
Mecca AP;Chen MK;O'Dell RS;Naganawa M;Toyonaga T;Godek TA;Harris JE;Bartlett HH;Zhao W;Banks ER;Ni GS;Rogers K;Gallezot JD;Ropchan J;Emery PR;Nabulsi NB;Vander Wyk BC;Arnsten AFT;Huang Y;Carson RE;van Dyck CH
早期神经病理改变的部位为阿尔茨海默病（AD）的初始临床特征提供了重要线索。我们发现阿尔茨海默病患者海马突触密度显著降低，这与通过穿孔通路投射到海马的内嗅皮质（ERC）细胞的早期变性一致。本研究通过PET检测了10例AD患者（5例轻度认知障碍，5例轻度痴呆）和10例认知正常受试者[11C]UCB-J与突触囊泡糖蛋白2A （SV2A）结合和[18F]flortaucipir与tau结合。在整个样本中，ERC tau与海马突触密度呈负相关（r= - 0.59， P=0.009）。在对部分体积效应进行校正后，ERC tau与海马突触密度的关联在整体样本中更强（r= - 0.61， P=0.007），在AD组中效应大小较大，但无统计学意义（r= - 0.58， P=0.06）。这种ERC tau与海马突触密度的负相关可能反映了ERC神经元中投射到海马的tau病理导致的突触失效。
Sites of early neuropathologic change provide important clues regarding the initial clinical features of Alzheimer’s disease (AD). We have shown significant reductions in hippocampal synaptic density in participants with AD, consistent with the early degeneration of entorhinal cortical (ERC) cells that project to hippocampus via the perforant path. In this study, [11C]UCB-J binding to synaptic vesicle glycoprotein 2A (SV2A) and [18F]flortaucipir binding to tau were measured via PET in 10 participants with AD (5 mild cognitive impairment, 5 mild dementia) and 10 cognitively normal participants. In the overall sample, ERC tau was inversely associated with hippocampal synaptic density (r=−0.59, P=0.009). After correction for partial volume effects, the association of ERC tau with hippocampal synaptic density was stronger in the overall sample (r=−0.61, P=0.007) and in the AD group where the effect size was large, but not statistically significant (r=−0.58, P=0.06). This inverse association of ERC tau and hippocampal synaptic density may reflect synaptic failure due to tau pathology in ERC neurons projecting to the hippocampus.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
3.5
作者：
de Jong, Hugo W. A. M.;van Velden, Floris H. P.;Lammertsma, Adriaan A.
通讯作者：
Lammertsma, Adriaan A.
影响因子：
3.3
作者：
Bussière, T;Gold, G;Hof, PR
通讯作者：
Hof, PR
DOI：
10.1186/s13195-021-00772-0
发表时间：
2021-02-05
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Coomans EM;Schoonhoven DN;Tuncel H;Verfaillie SCJ;Wolters EE;Boellaard R;Ossenkoppele R;den Braber A;Scheper W;Schober P;Sweeney SP;Ryan JM;Schuit RC;Windhorst AD;Barkhof F;Scheltens P;Golla SSV;Hillebrand A;Gouw AA;van Berckel BNM
通讯作者：
van Berckel BNM
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce