In vivo tau pathology is associated with synaptic loss and altered synaptic function.
In vivo tau pathology is associated with synaptic loss and altered synaptic function.
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在体内，tau的病理与突触丢失和突触功能改变有关。
DOI：
10.1186/s13195-021-00772-0
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发表时间：
2021-02-05
期刊：
影响因子：
--
通讯作者：
van Berckel BNM
中科院分区：
文献类型：
--
作者：
Coomans EM;Schoonhoven DN;Tuncel H;Verfaillie SCJ;Wolters EE;Boellaard R;Ossenkoppele R;den Braber A;Scheper W;Schober P;Sweeney SP;Ryan JM;Schuit RC;Windhorst AD;Barkhof F;Scheltens P;Golla SSV;Hillebrand A;Gouw AA;van Berckel BNM
阿尔茨海默病中突触丢失的机制目前尚不清楚，可能与 tau 病理学有关。在这项正电子发射断层扫描 (PET) 和脑磁图 (MEG) 联合研究中，我们旨在研究阿尔茨海默病中区域 tau 病理学 ([18F]flortaucipir PET)、突触密度（突触小泡 2A [11C]UCB-J PET）和突触功能 (MEG) 之间的空间关联。来自阿姆斯特丹痴呆队列的 7 名淀粉样蛋白阳性阿尔茨海默病受试者接受了动态 130 分钟 [18F]flortaucipir PET、动态 60 分钟 [11C]UCB-J PET（动脉采样）和 2 × 5 分钟静息态 MEG 测量。在感兴趣的大脑皮层区域评估[18F]flortaucipir和[11C]UCB-J特异性结合（结合电位，BPND）和MEG光谱测量（相对δ、θ和α功率；宽带功率；和峰值频率）。使用 Spearman 相关性和广义估计方程模型评估区域 [18F]flortaucipir BPND、[11C]UCB-J BPND 和 MEG 光谱测量之间的关联。在受试者中，较高的区域[18F]flortaucipir摄取与较低的[11C]UCB-J摄取相关。在受试者中，[11C]UCB-J 和 [18F]flortaucipir 之间的关联取决于受试者内新皮质 tau 负载；当新皮质 tau 负荷较高时，观察到负相关，随着新皮质 tau 负荷减少，逐渐转变为相反的模式。较高的[18F]flortaucipir和较低的[11C]UCB-J摄取均与突触功能改变相关，表明振荡活动减慢，在枕叶最为明显。这些结果表明，在阿尔茨海默病中，tau 蛋白病理学与突触密度降低和突触功能障碍密切相关。在线版本包含可在 10.1186/s13195-021-00772-0 获取的补充材料。
The mechanism of synaptic loss in Alzheimer’s disease is poorly understood and may be associated with tau pathology. In this combined positron emission tomography (PET) and magnetoencephalography (MEG) study, we aimed to investigate spatial associations between regional tau pathology ([18F]flortaucipir PET), synaptic density (synaptic vesicle 2A [11C]UCB-J PET) and synaptic function (MEG) in Alzheimer’s disease. Seven amyloid-positive Alzheimer’s disease subjects from the Amsterdam Dementia Cohort underwent dynamic 130-min [18F]flortaucipir PET, dynamic 60-min [11C]UCB-J PET with arterial sampling and 2 × 5-min resting-state MEG measurement. [18F]flortaucipir- and [11C]UCB-J-specific binding (binding potential, BPND) and MEG spectral measures (relative delta, theta and alpha power; broadband power; and peak frequency) were assessed in cortical brain regions of interest. Associations between regional [18F]flortaucipir BPND, [11C]UCB-J BPND and MEG spectral measures were assessed using Spearman correlations and generalized estimating equation models. Across subjects, higher regional [18F]flortaucipir uptake was associated with lower [11C]UCB-J uptake. Within subjects, the association between [11C]UCB-J and [18F]flortaucipir depended on within-subject neocortical tau load; negative associations were observed when neocortical tau load was high, gradually changing into opposite patterns with decreasing neocortical tau burden. Both higher [18F]flortaucipir and lower [11C]UCB-J uptake were associated with altered synaptic function, indicative of slowing of oscillatory activity, most pronounced in the occipital lobe. These results indicate that in Alzheimer’s disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction. The online version contains supplementary material available at 10.1186/s13195-021-00772-0.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
影响因子：
17.1
作者：
Finnema, Sjoerd J.;Nabulsi, Nabeel B.;Carson, Richard E.
通讯作者：
Carson, Richard E.
DOI：
10.1016/j.clinph.2018.03.042
发表时间：
2018-08
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Hari R;Baillet S;Barnes G;Burgess R;Forss N;Gross J;Hämäläinen M;Jensen O;Kakigi R;Mauguière F;Nakasato N;Puce A;Romani GL;Schnitzler A;Taulu S
通讯作者：
Taulu S
影响因子：
29
作者：
Chen, Ming-Kai;Mecca, Adam P.;van Dyck, Christopher H.
通讯作者：
van Dyck, Christopher H.
影响因子：
6.3
作者：
Finnema, Sjoerd J.;Nabulsi, Nabeel B.;Carson, Richard E.
通讯作者：
Carson, Richard E.