Tumor and Ablation Margin Visibility during Cryoablation of Musculoskeletal Tumors: Comparing Intraprocedural PET/CT Images with CT-Only Images.
Tumor and Ablation Margin Visibility during Cryoablation of Musculoskeletal Tumors: Comparing Intraprocedural PET/CT Images with CT-Only Images.
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DOI：
10.1016/j.jvir.2023.03.034
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发表时间：
2023-08
影响因子：
2.9
通讯作者：
Shyn, Paul B.
中科院分区：
文献类型：
--
作者：
Burch, Ezra A.;Bhagavatula, Sharath K.;Malone, Fiona E.;Reichert, Ryan R.;Tuncali, Kemal;Levesque, Vincent M.;Lan, Zhou;Sticka, William T.;Shyn, Paul B.
比较术中正电子发射断层扫描(PET)/计算机断层扫描（CT）和单纯CT图像上肿瘤和冰球边缘的可见性，并报告PET/CT引导下肌肉骨骼肿瘤冷冻消融手术的技术成功、局部肿瘤进展和不良事件发生率。这项符合HIPAA（健康保险可携带性和责任法案）和机构审查委员会批准的回顾性研究评估了2012年至2021年期间15名患者的15例肌肉骨骼肿瘤的20项PET/ ct引导冷冻消融手术，这些手术具有缓解和/或治疗目的。在全麻和PET/CT引导下进行冷冻消融。检查程序图像以确定以下内容：(a) PET/CT或仅CT图像是否可以充分评估肿瘤边界；(b)是否可以在PET/CT或仅CT图像上充分评估肿瘤冰球边缘。在PET/CT图像上显示肿瘤边界和冰球边缘的能力与仅在CT图像上进行比较。100% （20 / 20; 95% CI, 0.83-1）的PET/CT手术可完全评估肿瘤边界，而20% （4 / 20;95 CI, 0.057-0.44）的CT手术可完全评估肿瘤边界（P < 0.001）。80% （16 / 20, 95% CI, 0.56-0.94）的PET/CT手术可完全评估肿瘤冰球边缘，而5% （1 / 20,95% CI, 0.0013-0.25）的CT手术可完全评估肿瘤冰球边缘（P < 0.001）。75% （15 / 20; 95% CI, 0.51-0.91）的手术取得了初步技术成功。在至少6个月的随访中，23% （3/13;95% CI, 0.050-0.54）的治疗肿瘤出现局部进展。共有3例不良事件（1例3级、1例2级和1例1级）。与单独CT相比，PET/CT引导下的肌肉骨骼肿瘤冷冻消融可以提供更好的术中肿瘤和冰球边缘的可视化。需要进一步的研究来证实这种方法的长期有效性和安全性。
To compare tumor and ice-ball margin visibility on intraprocedural positron emission tomography (PET)/ computed tomography (CT) and CT-only images and report technical success, local tumor progression, and adverse event rates for PET/CT-guided cryoablation procedures for musculoskeletal tumors. This Health Insurance Portability and Accountability Act (HIPAA)–compliant and institutional review board–approved retrospective study evaluated 20 PET/CT-guided cryoablation procedures performed with palliative and/or curative intent to treat 15 musculoskeletal tumors in 15 patients from 2012 to 2021. Cryoablation was performed using general anesthesia and PET/CT guidance. Procedural images were reviewed to determine the following: (a) whether the tumor borders could be fully assessed on PET/CT or CT-only images; and (b) whether tumor ice-ball margins could be fully assessed on PET/CT or CT-only images. The ability to visualize tumor borders and ice-ball margins on PET/CT images was compared with that on CT-only images. Tumor borders were fully assessable for 100% (20 of 20; 95% CI, 0.83–1) of procedures on PET/CT versus 20% (4 of 20; 95 CI, 0.057–0.44) of procedures on CT only (P < .001). The tumor ice-ball margin was fully assessable in 80% (16 of 20; 95% CI, 0.56–0.94) of procedures using PET/CT versus 5% (1 of 20; 95% CI, 0.0013–0.25) of procedures using CT only (P < .001). Primary technical success was achieved in 75% (15 of 20; 95% CI, 0.51–0.91) of procedures. There was local tumor progression in 23% (3/13; 95% CI, 0.050–0.54) of the treated tumors with at least 6 months of follow-up. There were 3 adverse events (1 Grade 3, 1 Grade 2, and 1 Grade 1). PET/CT-guided cryoablation of musculoskeletal tumors can provide superior intraprocedural visualization of the tumor and ice-ball margins compared with that provided by CT alone. Further studies are warranted to confirm the long-term efficacy and safety of this approach.
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影响因子：
19.7
作者：
Shyn, Paul B.;Casadaban, Leigh C.;Silverman, Stuart G.
通讯作者：
Silverman, Stuart G.
影响因子：
2.9
作者：
Georgiades, Christos;Rodriguez, Ronald;Netto, George
通讯作者：
Netto, George
DOI：
10.1016/j.jvir.2009.12.403
发表时间：
2010-08
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Erinjeri JP;Clark TW
通讯作者：
Clark TW
DOI：
10.1007/s00259-021-05206-5
发表时间：
2021-02-09
影响因子：
9.1
作者：
Casadaban, Leigh C.;Catalano, Paul J.;Shyn, Paul B.
通讯作者：
Shyn, Paul B.
DOI：
10.1016/j.jvir.2010.11.027
发表时间：
2011-03-01
影响因子：
2.9
作者：
Sainani, Nisha I.;Shyn, Paul B.;Silverman, Stuart G.
通讯作者：
Silverman, Stuart G.