Reinforcement History Dependent Effects of Low Dose Ethanol on Reward Motivation in Male and Female Mice.
Reinforcement History Dependent Effects of Low Dose Ethanol on Reward Motivation in Male and Female Mice.
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DOI：
10.3389/fnbeh.2022.875890
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发表时间：
2022
影响因子：
3
通讯作者：
Barker, Jacqueline M.
中科院分区：
文献类型：
--
作者：
Bryant, Kathleen G.;Singh, Binay;Barker, Jacqueline M.
酒精使用障碍（AUDs）在男性中比女性更普遍，尽管女性的AUD诊断正在迅速增长，这使得了解酒精相关行为的性别差异变得越来越重要。AUD的发展涉及从随意的低水平饮酒到更高的适应不良水平的转变。低剂量酒精驱动奖赏和药物寻求的能力在男性和女性中可能不同，这可能是对AUD易感性差异的基础。在这项研究中，我们试图确定慢性低剂量乙醇暴露史（0.5 g/kg; i. p.）可以驱动蔗糖奖励寻求和动机，以及这是否在雄性和雌性小鼠之间存在差异。成年小鼠训练杠杆按液体蔗糖奖励两个强化时间表：随机间隔（RI）时间表和可变比率（VR）时间表。在训练之后，使用渐进比率测试对这些杠杆中的每一个测试小鼠的奖励动机。我们发现，历史上的低剂量乙醇暴露增加蔗糖奖励的动机，在雄性小鼠，但只有在RI杠杆，只有当曝光发生接近学习。无论乙醇暴露条件如何，雌性小鼠在RI水平上比VR水平上对蔗糖更有动力。这些发现表明，不同强化时间表的训练会影响奖励动机。此外，我们表明，男性更容易受到低剂量乙醇蔗糖奖励动机的影响比女性。这些数据拓宽了我们对乙醇暴露导致的奖励寻求的性别差异的理解。
Alcohol use disorders (AUDs) are more prevalent in men than in women, though AUD diagnoses in women are growing rapidly, making an understanding of sex differences in alcohol-related behaviors increasingly important. The development of AUDs involves the transition from casual, low levels of alcohol drinking to higher, maladaptive levels. The ability of low dose alcohol to drive reward and drug seeking may differ in males and females, and this could underlie differences in susceptibility to AUD. In this study we sought to determine whether a history of chronic, low dose ethanol exposure (0.5 g/kg; i.p.) could drive sucrose reward seeking and motivation, and whether this differed between male and female mice. Adult mice were trained to lever press for a liquid sucrose reward on two reinforcement schedules: a random interval (RI) schedule and a variable ratio (VR) schedule. After training, mice were tested on each of these levers for reward motivation using a progressive ratio test. We found that a history of low dose ethanol exposure increased sucrose reward motivation in male mice, but only on the RI lever and only when exposure occurred proximal to learning. Female mice were more motivated for sucrose on the RI lever than the VR lever regardless of ethanol exposure condition. These findings indicate that training on different reinforcement schedules affects reward motivation. Further, we show that males are more susceptible to the effects of low dose ethanol on sucrose reward motivation than females. These data broaden our understanding of sex differences in reward seeking as a result of ethanol exposure.
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影响因子：
13.8
作者：
Cui C;Koob GF
通讯作者：
Koob GF
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
7.7
作者：
Garcia-Sifuentes Y;Maney DL
通讯作者：
Maney DL
DOI：
10.1073/pnas.1308198110
发表时间：
2013-09-03
影响因子：
11.1
作者：
DePoy, Lauren;Daut, Rachel;Holmes, Andrew
通讯作者：
Holmes, Andrew
影响因子：
3.3
作者：
Ewin, Sarah E.;Morgan, James W.;Weiner, Jeffrey L.
通讯作者：
Weiner, Jeffrey L.