Are the dorsal and ventral hippocampus functionally distinct structures?

Are the dorsal and ventral hippocampus functionally distinct structures?
复制标题

DOI:
10.1016/j.neuron.2009.11.031
复制
发表时间:
2010-01-14
期刊:
影响因子:
16.2
通讯作者:
Dong, Hong-Wei
Dong, Hong-Wei
中科院分区:
医学1区
文献类型:
--
作者:
Fanselow, Michael S.;Dong, Hong-Wei

文献摘要

参考文献

被引文献

相似文献

一种文献将海马体视为与记忆有关的纯粹认知结构;另一种文献将其视为情绪调节器,其功能障碍导致精神病理学。我们回顾了行为,解剖和基因表达的研究,共同支持的功能分割成3海马隔室背侧,中间和腹侧。背侧海马,相当于灵长类动物的后部海马,主要执行认知功能。腹侧(灵长类动物的前部)与压力、情绪和情感有关。引人注目的是,背侧海马体中的基因表达与参与信息处理的皮质区域相关,而腹侧海马体中的基因表达与参与情绪和压力的区域(杏仁核和下丘脑)相关。
One literature treats the hippocampus as a purely cognitive structure involved in memory; another treats it as a regulator of emotion whose dysfunction leads to psychopathology. We review behavioral, anatomical, and gene expression studies that together support a functional segmentation into 3 hippocampal compartments dorsal, intermediate and ventral. The dorsal hippocampus, which corresponds to the posterior hippocampus in primates, performs primarily cognitive functions. The ventral (anterior in primates) relates to stress, emotion and affect. Strikingly, gene expression in the dorsal hippocampus correlates with cortical regions involved in information processing, while genes expressed in the ventral hippocampus correlate with regions involved in emotion and stress (amygdala and hypothalamus).
DOI: 10.1016/j.bbr.2008.09.030
发表时间: 2009-02-11
影响因子: 2.7
作者:
Clark EW;Bernstein IL
通讯作者: Bernstein IL
DOI: 10.1002/cne.21200
发表时间: 2007-02-01
影响因子: 2.5
作者:
Chrobak, James J.;Amaral, David G.
通讯作者: Amaral, David G.
DOI: 10.1016/s0168-0102(00)00183-8
发表时间: 2000-12-01
影响因子: 2.9
作者:
Chiba, T
通讯作者: Chiba, T
DOI: 10.1016/s0166-4328(02)00045-1
发表时间: 2002-08-21
影响因子: 2.7
作者:
Barrientos, RM;O'Reilly, RC;Rudy, JW
通讯作者: Rudy, JW
DOI: 10.1523/jneurosci.3781-04.2004
发表时间: 2004-12-08
影响因子: 5.3
作者:
Burwell, RD;Bucci, DJ;Jutras, MJ
通讯作者: Jutras, MJ