Are the dorsal and ventral hippocampus functionally distinct structures?
Are the dorsal and ventral hippocampus functionally distinct structures?
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DOI:
10.1016/j.neuron.2009.11.031
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发表时间:
2010-01-14
期刊:
影响因子:
16.2
通讯作者:
Dong, Hong-Wei
中科院分区:
文献类型:
--
作者:
Fanselow, Michael S.;Dong, Hong-Wei
One literature treats the hippocampus as a purely cognitive structure involved in memory; another treats it as a regulator of emotion whose dysfunction leads to psychopathology. We review behavioral, anatomical, and gene expression studies that together support a functional segmentation into 3 hippocampal compartments dorsal, intermediate and ventral. The dorsal hippocampus, which corresponds to the posterior hippocampus in primates, performs primarily cognitive functions. The ventral (anterior in primates) relates to stress, emotion and affect. Strikingly, gene expression in the dorsal hippocampus correlates with cortical regions involved in information processing, while genes expressed in the ventral hippocampus correlate with regions involved in emotion and stress (amygdala and hypothalamus).
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