Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.
Reduced neural feedback signaling despite robust neuron and gamma auditory responses during human sleep.
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在人类睡眠期间，尽管神经元和伽马听觉反应强烈，但神经反馈信号减弱。
DOI：
10.1038/s41593-022-01107-4
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发表时间：
2022-07
影响因子：
25
通讯作者：
Nir, Yuval
中科院分区：
文献类型：
--
作者：
Hayat, Hanna;Marmelshtein, Amit;Krom, Aaron J.;Sela, Yaniv;Tankus, Ariel;Strauss, Ido;Fahoum, Firas;Fried, Itzhak;Nir, Yuval
在睡眠期间，感官刺激很少触发行为反应或有意识的感知。然而，目前还不清楚睡眠是否会抑制感觉处理的特定方面，例如前馈或反馈信号。在这里，我们提出了听觉刺激（例如，点击列车，文字，音乐）在清醒和睡眠中的癫痫患者，同时记录神经元尖峰，微线局部场电位，颅内脑电图和多导睡眠图。在非快速眼动（NREM）和快速眼动（REM）睡眠期间，听觉刺激诱导了跨侧颞叶的稳健和选择性尖峰和高伽马（80-200 Hz）功率响应。睡眠仅适度衰减反应幅度，主要影响早期听觉皮层以外的晚期反应和NREM睡眠中快速点击列车的夹带。相比之下，清醒状态下普遍存在的睡眠诱导的α-β（10-30 Hz）去兴奋（即功率降低）在睡眠中大大减少。因此，广泛的听觉反应在睡眠期间持续存在，而α-β功率下降，可能反映神经反馈过程，是有缺陷的。更广泛地说，我们的发现表明反馈信号是有意识感觉处理的关键。人类皮质内记录显示，睡眠期间的听觉刺激会引起强烈的尖峰和高伽马反应，而α-β去极化可能反映了神经反馈过程与清醒状态相比有所减少。
During sleep, sensory stimuli rarely trigger a behavioral response or conscious perception. However, it remains unclear whether sleep inhibits specific aspects of sensory processing, such as feedforward or feedback signaling. Here, we presented auditory stimuli (for example, click-trains, words, music) during wakefulness and sleep in patients with epilepsy, while recording neuronal spiking, microwire local field potentials, intracranial electroencephalogram and polysomnography. Auditory stimuli induced robust and selective spiking and high-gamma (80–200 Hz) power responses across the lateral temporal lobe during both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Sleep only moderately attenuated response magnitudes, mainly affecting late responses beyond early auditory cortex and entrainment to rapid click-trains in NREM sleep. By contrast, auditory-induced alpha–beta (10–30 Hz) desynchronization (that is, decreased power), prevalent in wakefulness, was strongly reduced in sleep. Thus, extensive auditory responses persist during sleep whereas alpha–beta power decrease, likely reflecting neural feedback processes, is deficient. More broadly, our findings suggest that feedback signaling is key to conscious sensory processing. Intracortical recordings in humans reveal that auditory stimulation during sleep induces robust spiking and high-gamma responses, whereas alpha–beta desynchronization—likely reflecting neural feedback processes—is reduced compared to wakefulness.
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DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
影响因子：
9.8
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
2.5
作者：
Blume, Christine;del Giudice, Renata;Schabus, Manuel
通讯作者：
Schabus, Manuel
影响因子：
3.7
作者：
Canales-Johnson, Andres;Merlo, Emiliano;Arzi, Anat
通讯作者：
Arzi, Anat
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.