Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.

Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.
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DOI:
10.1016/j.devcel.2017.10.001
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发表时间:
2017-11-20
期刊:
影响因子:
11.8
通讯作者:
Fuchs E
Fuchs E
中科院分区:
生物学1区
文献类型:
--
作者:
Gonzales KAU;Fuchs E

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组织具有替代死亡细胞和愈合伤口的天然能力。这种能力存在于常驻干细胞中,在稳态和损伤期间,干细胞可以自我更新、保存和修复组织。皮肤表皮及其附属物每天都受到外界环境的侵害。为了保护身体免受感染和脱水以及伤口愈合,对皮肤屏障的更新和再生提出了很高的要求。本文综述了皮肤上皮干细胞的来源、分布及其在正常体内平衡和伤口修复中的作用。
Tissues have a natural capacity to replace dying cells and to heal wounds. This ability resides in resident stem cells, which self-renew, preserve, and repair their tissue during homeostasis and following injury. The skin epidermis and its appendages are subjected to daily assaults from the external environment. A high demand is placed on renewal and regeneration of the skin’s barrier in order to protect the body from infection and dehydration and to heal wounds. This review focuses on the epithelial stem cells of skin, where they come from, where they reside, and how they function in normal homeostasis and wound repair.
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