Expression Atlas update: gene and protein expression in multiple species.
Expression Atlas update: gene and protein expression in multiple species.
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表达图谱更新：多个物种的基因和蛋白质表达。
DOI：
10.1093/nar/gkab1030
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发表时间：
2022-01-07
影响因子：
14.9
通讯作者：
Papatheodorou I
中科院分区：
文献类型：
--
作者：
Moreno P;Fexova S;George N;Manning JR;Miao Z;Mohammed S;Muñoz-Pomer A;Fullgrabe A;Bi Y;Bush N;Iqbal H;Kumbham U;Solovyev A;Zhao L;Prakash A;García-Seisdedos D;Kundu DJ;Wang S;Walzer M;Clarke L;Osumi-Sutherland D;Tello-Ruiz MK;Kumari S;Ware D;Eliasova J;Arends MJ;Nawijn MC;Meyer K;Burdett T;Marioni J;Teichmann S;Vizcaíno JA;Brazma A;Papatheodorou I
EMBL-EBI表达图谱是一个增值知识库，使研究人员能够回答在哪里（组织，生物体部分，发育阶段，细胞类型）和在何种条件下（疾病，治疗，性别等）表达感兴趣的基因或蛋白质的问题。表达图谱汇集了来自超过65个不同物种的超过4500项表达研究的数据，涵盖不同的条件和组织。它使这些数据以易于可视化的形式免费提供，经过专家策展以准确表示预期的实验设计，通过依赖于开源社区开发工具的标准化管道进行重新分析。每个研究的元数据都使用本体进行注释。重新分析数据，目的是再现基础实验的原始结论。Expression Atlas目前分为Bulk Expression Atlas和Single Cell Expression Atlas。Expression Atlas包含来自差异研究（微阵列和批量RNA-Seq）和基线研究（批量RNA-Seq和蛋白质组学）的数据，而Single Cell Expression Atlas目前致力于单细胞RNA测序（scRNA-Seq）研究。该资源自2009年以来一直在持续开发，可在https://www.ebi.ac.uk/gxa上查阅。
The EMBL-EBI Expression Atlas is an added value knowledge base that enables researchers to answer the question of where (tissue, organism part, developmental stage, cell type) and under which conditions (disease, treatment, gender, etc) a gene or protein of interest is expressed. Expression Atlas brings together data from >4500 expression studies from >65 different species, across different conditions and tissues. It makes these data freely available in an easy to visualise form, after expert curation to accurately represent the intended experimental design, re-analysed via standardised pipelines that rely on open-source community developed tools. Each study's metadata are annotated using ontologies. The data are re-analyzed with the aim of reproducing the original conclusions of the underlying experiments. Expression Atlas is currently divided into Bulk Expression Atlas and Single Cell Expression Atlas. Expression Atlas contains data from differential studies (microarray and bulk RNA-Seq) and baseline studies (bulk RNA-Seq and proteomics), whereas Single Cell Expression Atlas is currently dedicated to Single Cell RNA-Sequencing (scRNA-Seq) studies. The resource has been in continuous development since 2009 and it is available at https://www.ebi.ac.uk/gxa.
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影响因子：
14.9
作者：
Harrison PW;Ahamed A;Aslam R;Alako BTF;Burgin J;Buso N;Courtot M;Fan J;Gupta D;Haseeb M;Holt S;Ibrahim T;Ivanov E;Jayathilaka S;Balavenkataraman Kadhirvelu V;Kumar M;Lopez R;Kay S;Leinonen R;Liu X;O'Cathail C;Pakseresht A;Park Y;Pesant S;Rahman N;Rajan J;Sokolov A;Vijayaraja S;Waheed Z;Zyoud A;Burdett T;Cochrane G
通讯作者：
Cochrane G
影响因子：
14.9
作者：
Arita M;Karsch-Mizrachi I;Cochrane G
通讯作者：
Cochrane G
DOI：
10.1093/bioinformatics/btx192
发表时间：
2017-08-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
da Veiga Leprevost F;Grüning BA;Alves Aflitos S;Röst HL;Uszkoreit J;Barsnes H;Vaudel M;Moreno P;Gatto L;Weber J;Bai M;Jimenez RC;Sachsenberg T;Pfeuffer J;Vera Alvarez R;Griss J;Nesvizhskii AI;Perez-Riverol Y
通讯作者：
Perez-Riverol Y
影响因子：
14.9
作者：
Harrison PW;Lopez R;Rahman N;Allen SG;Aslam R;Buso N;Cummins C;Fathy Y;Felix E;Glont M;Jayathilaka S;Kadam S;Kumar M;Lauer KB;Malhotra G;Mosaku A;Edbali O;Park YM;Parton A;Pearce M;Estrada Pena JF;Rossetto J;Russell C;Selvakumar S;Sitjà XP;Sokolov A;Thorne R;Ventouratou M;Walter P;Yordanova G;Zadissa A;Cochrane G;Blomberg N;Apweiler R
通讯作者：
Apweiler R
影响因子：
14.9
作者：
Papatheodorou, Irene;Moreno, Pablo;Brazma, Alvis
通讯作者：
Brazma, Alvis