PAIP2 is a potential diagnostic and prognostic biomarker of breast cancer and is associated with immune infiltration.
PAIP2 is a potential diagnostic and prognostic biomarker of breast cancer and is associated with immune infiltration.
复制标题
DOI：
10.3389/fgene.2022.1009056
复制
发表时间：
2022
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
乳腺癌是世界上发病率第二高的癌症。寻找生物标志物对乳腺癌的诊断和预测乳腺癌患者的预后具有重要意义。PAIP2是一种聚(a)结合蛋白相互作用蛋白，调节VEGF的表达。然而，PAIP2在乳腺癌进展中的可能作用尚不清楚。采用RT-qRCR和Western blotting验证PAIP2在乳腺癌细胞和正常乳腺细胞中的表达。在TCGA数据库和HPA数据库中获取乳腺癌样本数据，分析乳腺癌样本中PAIP2的表达情况。Transwell实验和CCK8实验证实了siRNA下调后PAIP2侵袭和增殖能力的变化。利用生物信息学技术探讨PAIP2的预后价值及其可能的生物学功能，以及对肿瘤免疫和免疫治疗的影响。研究表明，PAIP2在乳腺癌组织和乳腺癌细胞中有较高的表达。PAIP2可以促进乳腺癌细胞的增殖和侵袭，在肿瘤的高分期中有显著的高表达。PAIP2的高表达与乳腺癌患者更好的OS相关，与大多数化疗药物敏感性和癌症免疫治疗中的IPS呈负相关。我们的研究探索了PAIP2作为诊断和预后生物标志物的潜在价值，并可能预测免疫治疗的疗效，为后续研究PAIP2在乳腺癌中的作用提供参考。
Breast cancer is the second highest incidence of cancer in the world. It is of great significance to find biomarkers to diagnose breast cancer and predict the prognosis of breast cancer patients. PAIP2 is a poly (A) -binding protein interacting protein that regulates the expression of VEGF. However, the possible role of PAIP2 in the progression of breast cancer is still unknown. RT-qRCR and Western blotting were used to verify the expression of PAIP2 in breast cancer cells and normal breast cells. The data of breast cancer samples were obtained in the TCGA database and the HPA database to analyze the expression of PAIP2 in breast cancer samples. Transwell experiment and CCK8 experiment confirmed the changes in the invasion and proliferation ability of PAIP2 after siRNA was down-regulated. Using bioinformatics technology to explore the prognostic value of PAIP2 and its possible biological function, and its effect on tumor immunity and immunotherapy. Studies have shown that PAIP2 has higher expression in breast cancer tissues and breast cancer cells. PAIP2 can promote the proliferation and invasion of breast cancer cells and has significantly high expression in higher tumor stages. The high expression of PAIP2 is associated with better OS in breast cancer patients and is negatively correlated with most chemotherapeutic drug sensitivity and IPS in cancer immunotherapy. Our study explored the potential value of PAIP2 as a biomarker for diagnosis and prognosis and may predict the efficacy of immunotherapy, providing reference for the follow-up study on the role of PAIP2 in breast cancer.
血管内皮生长因子A和聚（A）结合蛋白相互作用蛋白2在人头和颈癌中的表达：相关性和预后意义。
影响因子：
8.8
作者：
Onesto, C.;Hannoun-Levi, J-M;Chamorey, E.;Formento, J-L;Ramaioli, A.;Pages, G.
通讯作者：
Pages, G.