Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance.
Vascular endothelial growth factor-A and Poly(A) binding protein-interacting protein 2 expression in human head and neck carcinomas: correlation and prognostic significance.
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血管内皮生长因子A和聚（A）结合蛋白相互作用蛋白2在人头和颈癌中的表达：相关性和预后意义。
DOI：
10.1038/sj.bjc.6603108
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发表时间：
2006-05-22
影响因子：
8.8
通讯作者：
Pages, G.
中科院分区：
文献类型：
--
作者：
Onesto, C.;Hannoun-Levi, J-M;Chamorey, E.;Formento, J-L;Ramaioli, A.;Pages, G.
关键词：
血管内皮生长因子-A（VEGF-A）在肿瘤血管生成中起重要作用，并影响许多癌症的预后。然而，其在头颈部鳞状细胞癌（HNSCCs）的预后价值仍存在争议。因此，我们研究了HNSCCs中VEGF-A表达的临床相关性，并分析了其表达是否与PAIP 2蛋白水平相关，PAIP 2蛋白是一种VEGF-A mRNA结合伴侣，在组织培养中强烈调节VEGF-A表达。我们确定了VEGF-A和PAIP 2蛋白水平的相关性，定量评估了54例HNSCC患者的肿瘤组织匀浆，临床病理参数。我们发现，VEGF-A在HNSCC中的表达与肿瘤分化阶段相关（P=0.050），并且是无进展生存期（P=0.001）和总生存期（P=0.0004）的独立预后因素。在咽癌细胞系中，我们通过RNA干扰证明VEGF-A的表达受PAIP 2的密切控制。此外，在人HNSCC中，VEGF-A表达与PAIP 2蛋白水平显著相关（P=0.0018）。然而，PAIP 2的表达与临床病理因素和患者的生存率均无关。我们的数据表明，与PAIP 2蛋白水平（与肿瘤预后无关）相反，VEGF-A表达可作为头颈癌的预后标志物，并可能有助于靶向治疗。
Vascular endothelial growth factor-A (VEGF-A) has been demonstrated to play an important role in tumour angiogenesis and to influence prognosis in many cancers. However its prognostic value in head and neck squamous cell carcinomas (HNSCCs) remains controversial. Therefore, we investigated the clinical relevance of VEGF-A expression in HNSCCs and analysed whether its expression was associated with PAIP2 protein levels, a VEGF-A mRNA-binding partner that strongly regulates VEGF-A expression in tissue culture. We determined the correlation of VEGF-A and PAIP2 protein levels, quantitatively evaluated in tumour tissue homogenates from 54 patients with HNSCC, to clinicopathological parameters. We showed that VEGF-A expression in HNSCC is correlated to the stage of tumour differentiation (P=0.050) and is an independent prognostic factor for progression-free survival (P=0.001) and overall survival (P=0.0004). In a pharynx carcinoma cell line, we demonstrated by RNA interference that VEGF-A expression is closely controlled by PAIP2. Moreover, in human HNSCCs, VEGF-A expression is significantly correlated to PAIP2 protein levels (P=0.0018). Nevertheless, PAIP2 expression is associated with neither clinicopathological factors nor patient's survival. Our data suggest that, in contrast to PAIP2 protein levels, which are unrelated to tumour prognosis, VEGF-A expression could serve as a prognostic marker in head and neck cancer and may be helpful for targeted therapies.
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