Acute Exercise has no Effect on Ghrelin Plasma Concentrations
Acute Exercise has no Effect on Ghrelin Plasma Concentrations
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急性运动对 Ghrelin 血浆浓度没有影响
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
M. Wolzt
中科院分区：
文献类型：
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作者：
Alice Schmidt;C. Maier;G. Schaller;P. Nowotny;M. Bayerle‐Eder;B. Buranyi;A. Luger;M. Wolzt
运动是生长激素(GH)分泌的一种有效的、剂量依赖的刺激。下丘脑肽、生长激素释放激素(GHRH)和生长抑素被认为是这种刺激的主要调节因子。胃源性多肽Ghrelin已被证明具有强烈的GH释放作用，但其作用尚未完全确定。因此，我们研究了8名健康年轻志愿者的GH和Ghrelin血浆浓度对不同运动水平的反应。在确定个人最大运动能力后，所有个体在不同的日期分别进行最大耗氧量(VO(2)max)的50%、70%和90%的跑步机运动。50%VO(2max)运动40min后GH反应最大，70%和90%VO(2max)运动20min后GH反应最大。血清GH浓度在三种运动强度下均显著升高(GH峰值浓度分别为5.8±2.3 ng/ml、12.0±3.2 ng/ml和9.8±4.7 ng/ml)。相比之下，Ghrelin血浆浓度在所有三种工作负荷下都保持不变。假设生长激素神经内分泌/代谢调节的敏感性没有改变，Ghrelin不参与健康男性对运动的生长激素反应的调节。
Exercise is a potent, dose-dependent stimulus of growth hormone (GH) secretion. The hypothalamic peptides, GH-releasing hormone (GHRH) and somatostatin are regarded as major regulators of this stimulation. The role of the stomach-derived peptide ghrelin, which has been shown to exert strong GH releasing effects, has not been fully characterized yet. We therefore studied GH and ghrelin plasma concentrations in response to graded levels of exercise in eight healthy young volunteers. After determination of their individual maximal exercise capacity, all individuals underwent a treadmill exercise at 50 %, 70 %, and 90 % of maximum oxygen consumption (VO (2)max) on different days. Maximal GH response to exercise was observed after 40 minutes at 50 % VO (2)max and after 20 minutes at 70 and 90 % VO (2max). GH serum concentrations increased significantly at all three exercise intensities (GH peak concentrations were 5.8 +/- 2.3 ng/ml, 12.0 +/- 3.2 ng/ml, and 9.8 +/- 4.7 ng/ml, respectively). In contrast, ghrelin plasma concentrations remained unchanged at all three workloads. Assuming that the sensitivity of the GH neuroendocrine/metabolic regulation of GH is unaltered, ghrelin does not participate in the regulation of the GH response to exercise in healthy males.
急性运动强度对男性脉动生长激素释放的影响。
DOI：
10.1152/jappl.1999.87.2.498
发表时间：
1999
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Pritzlaff,CJ;Wideman,L;Weltman,JY;Abbott,RD;Gutgesell,ME;Hartman,ML;Veldhuis,JD;Weltman,A
通讯作者：
Weltman,A