Dietary Phytoestrogens Ameliorate Hydrochloric Acid-Induced Chronic Lung Injury and Pulmonary Fibrosis in Mice.
Dietary Phytoestrogens Ameliorate Hydrochloric Acid-Induced Chronic Lung Injury and Pulmonary Fibrosis in Mice.
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DOI：
10.3390/nu13103599
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发表时间：
2021-10-14
期刊：
影响因子：
5.9
通讯作者：
Catravas JD
中科院分区：
文献类型：
--
作者：
Solopov P;Colunga Biancatelli RML;Dimitropoulou C;Catravas JD
我们之前曾报道过雌性小鼠对化学诱导的肺纤维化具有保护作用，并提出了雌激素的潜在作用。植物雌激素至少部分通过刺激雌激素受体发挥作用；此外，与西方国家的居民相比，东亚国家的居民消耗更多的植物雌激素，并表现出较低的肺纤维化发生率。因此，我们验证了饮食中的植物雌激素可以改善实验性肺纤维化的严重性这一假设。将雄性小鼠置于常规大豆饮食或不含植物雌激素的饮食中，向其体内注入0.1N盐酸以诱发肺纤维化。30d后测定肺力学指标作为肺功能指标，并分析肺组织和支气管肺泡灌洗液(BALF)中纤维化的生物标志物。与常规饮食的小鼠相比，无植物雌激素饮食的小鼠表现出更高的死亡率和更强的慢性肺损伤和肺纤维化的迹象，这反映在胶原蛋白的表达、细胞外基质沉积、组织学和肺力学上。我们的结论是，饮食中的植物雌激素在肺纤维化的发病机制中起着重要的作用，并提示植物雌激素(如染料木素)可能作为抗盐酸诱导的肺纤维化和慢性肺功能障碍的治疗方案的一部分。
We previously reported that female mice exhibit protection against chemically induced pulmonary fibrosis and suggested a potential role of estrogen. Phytoestrogens act, at least in part, via stimulation of estrogen receptors; furthermore, compared to residents of Western countries, residents of East Asian countries consume higher amounts of phytoestrogens and exhibit lower rates of pulmonary fibrosis. Therefore, we tested the hypothesis that dietary phytoestrogens ameliorate the severity of experimentally induced pulmonary fibrosis. Male mice placed on either regular soybean diet or phytoestrogen-free diet were instilled with 0.1 N HCl to provoke pulmonary fibrosis. Thirty days later, lung mechanics were measured as indices of lung function and bronchoalveolar lavage fluid (BALF) and lung tissue were analyzed for biomarkers of fibrosis. Mice on phytoestrogen-free diet demonstrated increased mortality and stronger signs of chronic lung injury and pulmonary fibrosis, as reflected in the expression of collagen, extracellular matrix deposition, histology, and lung mechanics, compared to mice on regular diet. We conclude that dietary phytoestrogens play an important role in the pathogenesis of pulmonary fibrosis and suggest that phytoestrogens (e.g., genistein) may be useful as part of a therapeutic regimen against hydrochloric acid-induced lung fibrosis and chronic lung dysfunction.
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影响因子：
5.6
作者：
Colunga Biancatelli RML;Solopov P;Dimitropoulou C;Catravas JD
通讯作者：
Catravas JD
影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
3.7
作者：
Setzer F;Schmidt B;Hueter L;Schwarzkopf K;Sänger J;Schreiber T
通讯作者：
Schreiber T
DOI：
10.5114/aoms.2013.36929
发表时间：
2013-08-30
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Guo Y;Zhang A;Ding Y;Wang Y;Yuan W
通讯作者：
Yuan W
影响因子：
5.4
作者：
Kim，Ji Min;Kim，Jeong Hun;Lee，Byung-Joo
通讯作者：
Lee，Byung-Joo