Subcellular Targeting of Theranostic Radionuclides.
Subcellular Targeting of Theranostic Radionuclides.
复制标题
DOI：
10.3389/fphar.2018.00996
复制
发表时间：
2018
影响因子：
5.6
通讯作者：
Vallis KA
中科院分区：
文献类型：
--
作者：
Bavelaar BM;Lee BQ;Gill MR;Falzone N;Vallis KA
在过去的十年中，放射性核素在各种癌症的治疗和成像中的应用迅速增长。放射性核素治疗和成像依赖于放射性标记载体特异性靶向癌细胞。发射β粒子的放射性核素迄今为止在靶向放射性核素治疗（TRT）领域占据主导地位，主要是因为这些粒子的较长范围（μm-mm径迹长度）抵消了分子靶标的异质表达。另一方面，较短的（nm - μm径迹长度）α-和俄格电子（AE）发射放射性核素在衰变部位提供高电离密度，可以克服与β-发射器相关的大部分毒性。鉴于越来越多的证据表明，除了DNA之外的其他敏感部位，如细胞膜和线粒体，可能是TRT的关键靶点，因此有必要改进检测这些放射性核素亚细胞分布的技术，特别是因为许多β-发射放射性核素也发射AE。成功开发能够以亚细胞精度定位目标的TRT试剂需要并行开发用于评估放射性核素在nm -μm范围内空间分布的定量分析。本文综述了放射性核素亚细胞靶向治疗的研究现状，以及纳米尺度放射性核素定位的成像和定量方法。
The last decade has seen rapid growth in the use of theranostic radionuclides for the treatment and imaging of a wide range of cancers. Radionuclide therapy and imaging rely on a radiolabeled vector to specifically target cancer cells. Radionuclides that emit β particles have thus far dominated the field of targeted radionuclide therapy (TRT), mainly because the longer range (μm–mm track length) of these particles offsets the heterogeneous expression of the molecular target. Shorter range (nm–μm track length) α- and Auger electron (AE)-emitting radionuclides on the other hand provide high ionization densities at the site of decay which could overcome much of the toxicity associated with β-emitters. Given that there is a growing body of evidence that other sensitive sites besides the DNA, such as the cell membrane and mitochondria, could be critical targets in TRT, improved techniques in detecting the subcellular distribution of these radionuclides are necessary, especially since many β-emitting radionuclides also emit AE. The successful development of TRT agents capable of homing to targets with subcellular precision demands the parallel development of quantitative assays for evaluation of spatial distribution of radionuclides in the nm–μm range. In this review, the status of research directed at subcellular targeting of radionuclide theranostics and the methods for imaging and quantification of radionuclide localization at the nanoscale are described.
登录
查看更多内容
影响因子：
--
作者：
A L Darwish R;Staudacher AH;Bezak E;Brown MP
通讯作者：
Brown MP
DOI：
10.1016/j.ejmp.2018.05.020
发表时间：
2018-07-01
影响因子：
3.4
作者：
Ackerman, Nicole L.;Rosales, Liset de la Fuente;Bernal, Mario A.
通讯作者：
Bernal, Mario A.
影响因子：
4.6
作者：
Dekempeneer Y;Keyaerts M;Krasniqi A;Puttemans J;Muyldermans S;Lahoutte T;D'huyvetter M;Devoogdt N
通讯作者：
Devoogdt N
影响因子：
9.3
作者：
Cai, Zhongli;Chen, Zhuo;Vallis, Katherine A.
通讯作者：
Vallis, Katherine A.
影响因子：
9.3
作者：
Chouin, Nicolas;Lindegren, Sture;Back, Tom
通讯作者：
Back, Tom